Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/68461
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dc.titleWater-soluble conjugated polymers as the platform for protein sensors
dc.contributor.authorLi, K.
dc.contributor.authorLiu, B.
dc.date.accessioned2014-06-18T06:13:34Z
dc.date.available2014-06-18T06:13:34Z
dc.date.issued2010-05
dc.identifier.citationLi, K., Liu, B. (2010-05). Water-soluble conjugated polymers as the platform for protein sensors. Polymer Chemistry 1 (3) : 252-259. ScholarBank@NUS Repository.
dc.identifier.issn17599954
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/68461
dc.description.abstractThe booming development of protein detection requires simple, sensitive, and reliable biosensor systems. Water-soluble conjugated polymers have been widely used for protein sensing due to their distinct optical response in the presence of different analytes. This review summarizes the recent developments in water-soluble conjugated polymer-based protein sensors. Based on the different optical responses of conjugated polymers to proteins, these assays are categorized into three groups. The conformational change of cationic poly(thiophene)s is used to generate unique colorimetric or fluorescent transduction upon interaction with target proteins. Super-quenching of water-soluble poly(phenylene vinylene)s and poly(phenylene ethynylene)s has been developed into fluorescence turn-on and turn-off protein assays. Energy transfer between poly(fluorene-co-phenylene) derivatives and acceptor dyes is also utilized to develop fluorescence turn-on protein assays with amplified signal output. The fine-tuning of conjugated polymer structures will benefit the design of versatile optical probes to satisfy the sophisticated requirements for protein sensors. © 2010 The Royal Society of Chemistry.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1039/b9py00283a
dc.sourceScopus
dc.typeReview
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.sourcetitlePolymer Chemistry
dc.description.volume1
dc.description.issue3
dc.description.page252-259
dc.identifier.isiut000278602800002
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