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|Title:||Enhanced microfiltration devices configured with hydrodynamic trapping and a rain drop bypass filtering architecture for microbial cells detection||Authors:||Lay, C.
|Issue Date:||2008||Citation:||Lay, C., Teo, C.Y., Zhu, L., Peh, X.L., Ji, H.M., Chew, B.-R., Murthy, R., Feng, H.H., Liu, W.-T. (2008). Enhanced microfiltration devices configured with hydrodynamic trapping and a rain drop bypass filtering architecture for microbial cells detection. Lab on a Chip - Miniaturisation for Chemistry and Biology 8 (5) : 830-833. ScholarBank@NUS Repository. https://doi.org/10.1039/b800015h||Abstract:||Ultra-fine (<1 μm) microfilters are required to effectively trap microbial cells. We designed microfilters featuring a rain drop bypass architecture, which significantly reduces the likelihood of clogging at the cost of limited cell loss. The new rain drop bypass architecture configuration has a substantially lower pressure drop and allows a better efficiency in trapping protozoan cells (Cryptosporidium parvum and Giardia lamblia) in comparison to our previous generation of a microfilter device. A modified version displaying sub-micron filter gaps was adapted to trap and detect bacterial cells (Escherichia coli), through a method of cells labeling, which aims to amplify the fluorescence signal emission and therefore the sensitivity of detection. © The Royal Society of Chemistry.||Source Title:||Lab on a Chip - Miniaturisation for Chemistry and Biology||URI:||http://scholarbank.nus.edu.sg/handle/10635/67645||ISSN:||14730197||DOI:||10.1039/b800015h|
|Appears in Collections:||Staff Publications|
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