Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.colsurfb.2005.08.016
DC FieldValue
dc.titleApplication of TPGS in polymeric nanoparticulate drug delivery system
dc.contributor.authorMu, L.
dc.contributor.authorSeow, P.H.
dc.date.accessioned2014-06-17T09:42:21Z
dc.date.available2014-06-17T09:42:21Z
dc.date.issued2006-01-15
dc.identifier.citationMu, L., Seow, P.H. (2006-01-15). Application of TPGS in polymeric nanoparticulate drug delivery system. Colloids and Surfaces B: Biointerfaces 47 (1) : 90-97. ScholarBank@NUS Repository. https://doi.org/10.1016/j.colsurfb.2005.08.016
dc.identifier.issn09277765
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/66929
dc.description.abstractD-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) has great potential in pharmacology and nanotechnology. The present work investigated the molecular behaviour of TPGS at the air-water interface, its effect on a model bio-membrane composed of dipalmitoylphosphatidylcholine (DPPC) lipid monolayer, and the interaction between the TPGS coated nanoparticles with the lipid model membrane. Paclitaxel loaded polymeric nanoparticles with TPGS as surfactant stabiliser were fabricated and characterised in terms of their drug incorporation capability and release kinetics. The result showed that TPGS exhibited notable effect on the surface properties of air-water interface as well as the lipid monolayer. The inter-particle force and the interaction between nanoparticles and lipid monolayer varied with the surface substance. The penetration of various nanoparticles into the model membrane indicated that an optimal balance between hydrophilicity and hydrophobicity on nanoparticle surface is needed to achieve an effective cellular uptake of nanoparticles. The results also demonstrate that the drug incorporation capability and the release characteristics of drug-loaded nanoparticles can be influenced by surfactant stabiliser. © 2005 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.colsurfb.2005.08.016
dc.sourceScopus
dc.subjectBiodegradable polymer
dc.subjectControlled release
dc.subjectD-α-Tocopheryl polyethylene glycol 1000 succinate
dc.subjectDrug-cell membrane interaction
dc.subjectEmulsifier
dc.subjectNanoparticles
dc.subjectPaclitaxel
dc.subjectStabiliser
dc.subjectSurfactant
dc.subjectTaxol
dc.typeArticle
dc.contributor.departmentBIOENGINEERING
dc.description.doi10.1016/j.colsurfb.2005.08.016
dc.description.sourcetitleColloids and Surfaces B: Biointerfaces
dc.description.volume47
dc.description.issue1
dc.description.page90-97
dc.description.codenCSBBE
dc.identifier.isiut000235102600013
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