Please use this identifier to cite or link to this item: https://doi.org/10.1002/bit.10571
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dc.titleComputer simulation of the delivery of etanidazole to brain tumor from PLGA wafers: Comparison between linear and double burst release systems
dc.contributor.authorTan, W.H.K.
dc.contributor.authorWang, F.
dc.contributor.authorLee, T.
dc.contributor.authorWang, C.-H.
dc.date.accessioned2014-06-17T08:31:04Z
dc.date.available2014-06-17T08:31:04Z
dc.date.issued2003-05-05
dc.identifier.citationTan, W.H.K., Wang, F., Lee, T., Wang, C.-H. (2003-05-05). Computer simulation of the delivery of etanidazole to brain tumor from PLGA wafers: Comparison between linear and double burst release systems. Biotechnology and Bioengineering 82 (3) : 278-288. ScholarBank@NUS Repository. https://doi.org/10.1002/bit.10571
dc.identifier.issn00063592
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/66499
dc.description.abstractThis paper presents the computer simulation results on the delivery of Etanidazole (radiosensitizer) to the brain tumor and examines several factors affecting the delivery. The simulation consists of a 3D model of tumor with poly(lactide-co-glycolide) (PLGA) wafers with 1% Etanidazole loading implanted in the resected cavity. A zero-order release device will produce a concentration profile in the tumor which increases with time until the drug in the carrier is depleted. This causes toxicity complications during the later stages of drug treatment. However, for wafers of similar loading, such release results in a higher drug penetration depth and therapeutic index as compared to the double drug burst profile. The numerical accuracy of the model was verified by the similar results obtained in the two-dimensional and threedimensional models. © 2003 Wiley Periodicals, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/bit.10571
dc.sourceScopus
dc.subjectConvection
dc.subjectDrug delivery system
dc.subjectElimination
dc.subjectEtanidazole
dc.subjectPenetration distance
dc.subjectTherapeutic index
dc.typeArticle
dc.contributor.departmentCHEMICAL & ENVIRONMENTAL ENGINEERING
dc.description.doi10.1002/bit.10571
dc.description.sourcetitleBiotechnology and Bioengineering
dc.description.volume82
dc.description.issue3
dc.description.page278-288
dc.description.codenBIBIA
dc.identifier.isiut000181784100004
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