Synthesis and properties of poly(d,l-lactide) drug carrier with maghemite nanoparticles

Abstract

A magnetic polymeric carrier, composed of biodegradable poly(d,l-lactide) microspheres, maghemite nanoparticles and anti-cancer drug (paclitaxel) was successfully prepared in dichloromethane using high-speed homogenization. Maghemite nanoparticles were well dispersed in PLA matrix. The carrier was magnetically responsive and exhibited low cytotoxicity. Release of loaded paclitaxel was enhanced by applying an oscillating magnetic field. The thermal energy generated by maghemite nanoparticles due to magnetic hysteresis loss was very low and considered negligible in influencing the release behavior. Alternating movement of the nanoparticles, stimulated by magnetic force, resulting in deterioration of the mechanical properties of polymer matrix was likely to be the main reason for the enhancement in drug release. Crown Copyright © 2010.