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Title: The nano spray dryer B-90
Authors: Heng, D.
Lee, S.H.
Ng, W.K.
Tan, R.B. 
Keywords: drug delivery
electrostatic particle collector
nano spray dryer
nanoparticles and microparticles
spray drying
vibrating mesh spray technology
Issue Date: Jul-2011
Citation: Heng, D., Lee, S.H., Ng, W.K., Tan, R.B. (2011-07). The nano spray dryer B-90. Expert Opinion on Drug Delivery 8 (7) : 965-972. ScholarBank@NUS Repository.
Abstract: Introduction: Spray drying is an extremely well-established technology for the production of micro-particulate powders suited for a variety of drug delivery applications. In recent years, the rise in nanomedicine has placed increased pressure on the existing systems to produce nanoparticles in good yield and with a narrow size distribution. However, the separation and collection of nanoparticles with conventional spray dryer set ups is extremely challenging due to their typical low collection efficiency for fine particles < 2 μm. Currently, nanoparticles have to be agglomerated into larger microparticles, via a two-step approach, in order to collect them in a sizeable amount. However, this method has to contend with the issue of adequate redispersibility of the primary particles to reap the full benefits of nanosizing. Areas covered: An overview on the advances in spray drying technology is provided in this review with particular emphasis on the novel Buchi Nano Spray Dryer B-90. Readers will appreciate the limitations of conventional spray drying technology, understand the mechanisms of the Buchi Nano Spray Dryer B-90, and also learn about the strengths and shortcomings of the system. Expert opinion: The Buchi Nano Spray Dryer B-90 offers a new, simple and alternative approach for the production of nanoparticles suited for a variety of drug delivery applications. © 2011 Informa UK, Ltd.
Source Title: Expert Opinion on Drug Delivery
ISSN: 17425247
DOI: 10.1517/17425247.2011.588206
Appears in Collections:Staff Publications

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