Please use this identifier to cite or link to this item: https://doi.org/10.1002/jps.21967
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dc.titleStabilized amorphous state of ibuprofen by co-spray drying with mesoporous SBA-15 to enhance dissolution properties
dc.contributor.authorShen, S.-C.
dc.contributor.authorNg, W.K.
dc.contributor.authorChia, L.
dc.contributor.authorDong, Y.-C.
dc.contributor.authorTan, R.B.H.
dc.date.accessioned2014-06-17T07:49:18Z
dc.date.available2014-06-17T07:49:18Z
dc.date.issued2010-04
dc.identifier.citationShen, S.-C., Ng, W.K., Chia, L., Dong, Y.-C., Tan, R.B.H. (2010-04). Stabilized amorphous state of ibuprofen by co-spray drying with mesoporous SBA-15 to enhance dissolution properties. Journal of Pharmaceutical Sciences 99 (4) : 1997-2007. ScholarBank@NUS Repository. https://doi.org/10.1002/jps.21967
dc.identifier.issn00223549
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/64615
dc.description.abstractA novel formulation process via co-spray drying ibuprofen (IBU) with mesoporous SBA-15 submicron particles exhibited excellence in production of stable amorphous IBU with significantly enhanced dissolution rate. With drug loading of IBU/SBA-15 ratio being 50:50 (w/w) or below, most drug molecules were entrapped inside the straight mesoporous channels via the co-spray drying and the morphology of SBA-15 submicron particles remained unchanged. IBU confined inside the mesoporous structure was in the amorphous state shown by PXRD and DSC measurements. The amorphous state of IBU in the solid dispersion showed remarkable stability when subject to stress test condition of 408C/75% RH in open pans for 12 months. The uniform pore walls were believed to prevent the re-crystallization of the homogeneously dispersed drug molecules inside the mesoporous channels with confined nanospace. The dissolution rate of IBU from the co-spray-dried solid dispersion was significantly enhanced to achieve a rapid release. Even after the accelerated stability test, the rapid drug release property was well preserved. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/jps.21967
dc.sourceScopus
dc.subjectAmorphous
dc.subjectCo-spray drying
dc.subjectPoorly soluble drugs
dc.subjectRapid release
dc.subjectSBA-15
dc.subjectStability
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1002/jps.21967
dc.description.sourcetitleJournal of Pharmaceutical Sciences
dc.description.volume99
dc.description.issue4
dc.description.page1997-2007
dc.description.codenJPMSA
dc.identifier.isiut000276226300028
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