Please use this identifier to cite or link to this item:
Title: Effects of polydisperse crowders on aggregation reactions: A molecular thermodynamic analysis
Authors: Shah, D.
Tan, A.L.
Ramakrishnan, V.
Jiang, J. 
Rajagopalan, R. 
Issue Date: 14-Feb-2011
Citation: Shah, D., Tan, A.L., Ramakrishnan, V., Jiang, J., Rajagopalan, R. (2011-02-14). Effects of polydisperse crowders on aggregation reactions: A molecular thermodynamic analysis. Journal of Chemical Physics 134 (6) : -. ScholarBank@NUS Repository.
Abstract: Intracellular crowding in biological systems is usually mimicked in in vitro experiments by adding single crowders at high volume fractions, without taking into consideration the polydispersity of the crowders in the cellular environment. Here, we develop a molecular thermodynamic formalism to examine the effects of size-polydispersity of crowders on aggregation reaction equilibria. Although the predominantly common practice so far has been to appeal to the entropic (excluded-volume) effects in describing crowding effects, we show that the internal energy (hence, the enthalpy) of the system could dramatically alter the effects, even qualitatively, particularly in the case of a mixture of crowders, depending on the changes in the covolume of the products relative to that of the reactants and on the preferential binding or exclusion of the crowders by the reactants and products. We also show that in the case of polydisperse crowders the crowders with the largest size difference dominate the overall changes in the yield of the reaction, depending on the individual concentrations of the crowders. © 2011 American Institute of Physics.
Source Title: Journal of Chemical Physics
ISSN: 00219606
DOI: 10.1063/1.3549906
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.