Please use this identifier to cite or link to this item: https://doi.org/10.1002/jbm.a.32867
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dc.titleCore/shell microspheres via coaxial electrohydrodynamic atomization for sequential and parallel release of drugs
dc.contributor.authorNie, H.
dc.contributor.authorDong, Z.
dc.contributor.authorArifin, D.Y.
dc.contributor.authorHu, Y.
dc.contributor.authorWang, C.-H.
dc.date.accessioned2014-06-17T07:38:11Z
dc.date.available2014-06-17T07:38:11Z
dc.date.issued2010-12-01
dc.identifier.citationNie, H., Dong, Z., Arifin, D.Y., Hu, Y., Wang, C.-H. (2010-12-01). Core/shell microspheres via coaxial electrohydrodynamic atomization for sequential and parallel release of drugs. Journal of Biomedical Materials Research - Part A 95 (3 A) : 709-716. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.a.32867
dc.identifier.issn15493296
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/63672
dc.description.abstractHerein, it is demonstrated that coaxial electrohydrodynamic atomization can be used for the fabrication of microspheres with distinct core/shell structure. This allows the encapsulation of two different types of drugs in different compartments in one single step. In Group A, we prepared microspheres in which the core and the shell contain hydrophobic and hydrophilic drugs, respectively. In contrast, in Group B, the opposite is prepared. While the former can be achieved by using amphiphilic polymers in aqueous environment, the latter is difficult to be prepared. The release patterns of the two groups are significantly different. The release of drugs from Group A microspheres is rather sequential, whereas group B microspheres release drugs in a parallel (co-release) manner. Nevertheless, in both groups, we found that the release of drugs can be easily tailored by altering outer/inner flow ratios. These findings present the advantages and possible application of this multi-drug release system in chemotherapy. Moreover, cell culture experiments have been performed to testify the performances of different microspheres in cytotoxicity and cellular apoptosis in vitro. © 2010 Wiley Periodicals, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/jbm.a.32867
dc.sourceScopus
dc.subjectCoaxial electrohydrodynamic atomization
dc.subjectCore/shell microspheres
dc.subjectDrug delivery
dc.subjectParallel release
dc.subjectSequential release
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1002/jbm.a.32867
dc.description.sourcetitleJournal of Biomedical Materials Research - Part A
dc.description.volume95
dc.description.issue3 A
dc.description.page709-716
dc.description.codenJBMRC
dc.identifier.isiut000283959800006
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