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https://doi.org/10.1039/c004491a
DC Field | Value | |
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dc.title | Conformational and enantiotropic polymorphism of a 1:1 cocrystal involving ethenzamide and ethylmalonic acid | |
dc.contributor.author | Aitipamula, S. | |
dc.contributor.author | Chow, P.S. | |
dc.contributor.author | Tan, R.B.H. | |
dc.date.accessioned | 2014-06-17T07:37:44Z | |
dc.date.available | 2014-06-17T07:37:44Z | |
dc.date.issued | 2010-11 | |
dc.identifier.citation | Aitipamula, S., Chow, P.S., Tan, R.B.H. (2010-11). Conformational and enantiotropic polymorphism of a 1:1 cocrystal involving ethenzamide and ethylmalonic acid. CrystEngComm 12 (11) : 3691-3697. ScholarBank@NUS Repository. https://doi.org/10.1039/c004491a | |
dc.identifier.issn | 14668033 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/63633 | |
dc.description.abstract | Polymorphism in cocrystals is increasingly gaining interest because of the overwhelming interest in pharmaceutical cocrystals. In this paper, we report a 1:1 cocrystal of an analgesic drug, ethenzamide (EA), with ethylmalonic acid (EMA) which exists in two polymorphic forms. Both the polymorphs were characterized by various analytical techniques, such as single-crystal and powder X-ray diffraction, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), hot-stage microscopy (HSM) and variable temperature X-ray diffraction (VTXRD). Crystal structure analysis suggests that the EMA molecules in both the polymorphs adopt different conformations but feature a common hydrogen bonding motif. Thermal analysis suggests that the polymorphs are related enantiotropically. Based on the information obtained from the thermal data and various other experiments, a semi-schematic energy-temperature diagram was constructed. Interestingly, it was observed that the polymorphic outcome of solid-state grinding is remarkably dependent on the polarity of the solvent used in the solvent-drop grinding experiments. © 2010 The Royal Society of Chemistry. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1039/c004491a | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | CHEMICAL & BIOMOLECULAR ENGINEERING | |
dc.description.doi | 10.1039/c004491a | |
dc.description.sourcetitle | CrystEngComm | |
dc.description.volume | 12 | |
dc.description.issue | 11 | |
dc.description.page | 3691-3697 | |
dc.identifier.isiut | 000283315900063 | |
Appears in Collections: | Staff Publications |
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