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Title: Amphiphilic polymeric nanocarriers with luminescent gold nanoclusters for concurrent bioimaging and controlled drug release
Authors: Chen, D.
Luo, Z.
Li, N.
Lee, J.Y. 
Xie, J. 
Lu, J.
Keywords: amphiphilic polymer carriers
biomedical applications
composite materials
luminescent nanoclusters
Issue Date: 20-Sep-2013
Citation: Chen, D., Luo, Z., Li, N., Lee, J.Y., Xie, J., Lu, J. (2013-09-20). Amphiphilic polymeric nanocarriers with luminescent gold nanoclusters for concurrent bioimaging and controlled drug release. Advanced Functional Materials 23 (35) : 4324-4331. ScholarBank@NUS Repository.
Abstract: Multifunctional theranostic systems with good biocompatibility, strong clinical imaging capability, and target specificity are the desired features of future medicine. Here, the design of a theranostic nanocomposite capable of simultaneous targeting and imaging of the cancer cells is presented. It releases its drug payload by a controlled release mechanism. The nanocomposite contains luminescent gold nanocluster (L-AuNC) photostable and biocompatible diagnostic probes conjugated to a folic acid (FA)-modified pH-responsive amphiphilic polymeric system for controlled drug release. The nanocomposite uses a core-satellite structure to encapsulate hydrophobic drugs and releases the drug payload in mildly acidic endosomal/lysosomal compartments by the action of the pH-labile linkages in the polymer. In vivo studies show the selective accumulation of the FA-conjugated nanocomposite in tumor tissues by folate-receptor-mediated endocytosis. These findings demonstrate the potential of the nanocomposite as a nontoxic, folate-targeting, pH-responsive drug carrier that is useful for the early detection and therapy of folate-overexpressing cancerous cells. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Advanced Functional Materials
ISSN: 1616301X
DOI: 10.1002/adfm.201300411
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