Please use this identifier to cite or link to this item: https://doi.org/10.1002/aic.12373
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dc.titleAcid-sensitive magnetic nanoparticles as potential drug depots
dc.contributor.authorWuang, S.C.
dc.contributor.authorNeoh, K.G.
dc.contributor.authorKang, E.-T.
dc.contributor.authorLeckband, D.E.
dc.contributor.authorPack, D.W.
dc.date.accessioned2014-06-17T07:35:23Z
dc.date.available2014-06-17T07:35:23Z
dc.date.issued2011-06
dc.identifier.citationWuang, S.C., Neoh, K.G., Kang, E.-T., Leckband, D.E., Pack, D.W. (2011-06). Acid-sensitive magnetic nanoparticles as potential drug depots. AIChE Journal 57 (6) : 1638-1645. ScholarBank@NUS Repository. https://doi.org/10.1002/aic.12373
dc.identifier.issn00011541
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/63428
dc.description.abstractSuperparamagnetic magnetic nanoparticles were successfully functionalized with poly(methacrylic acid) via atom transfer radical polymerization, followed by conjugation to doxorubicin (Dox). Because of pH-sensitive hydrazone linkages, the rate and extent of Dox release from the particles was higher at a lower pH and/or a higher temperature than at physiological conditions. Appropriate changes to the pH and temperature can increase the drug release from the particles. Because of the released drug, the particles were found to be cytotoxic to human breast cancer cells in vitro. Such magnetic nanoparticles, with the potential to retain drug under physiological conditions and release the drug in conditions where the pH is lower or temperature is higher, may be useful in magnetic drug targeting by reducing the side effects of the drug caused to healthy tissues. In addition, they may serve as hyperthermia agents where the high temperatures used in hyperthermia can trigger further drug release. © 2010 American Institute of Chemical Engineers (AIChE).
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/aic.12373
dc.sourceScopus
dc.subjectCancer cells
dc.subjectConjugation
dc.subjectDoxorubicin
dc.subjectHydrazone linkages
dc.subjectMagnetic drug targeting
dc.subjectMagnetic nanoparticles
dc.subjectPoly(methacrylic acid)
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.contributor.departmentBIOENGINEERING
dc.description.doi10.1002/aic.12373
dc.description.sourcetitleAIChE Journal
dc.description.volume57
dc.description.issue6
dc.description.page1638-1645
dc.description.codenAICEA
dc.identifier.isiut000290616500024
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