Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2003.08.038
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dc.titleSurface modification of ultra thin poly (ε-caprolactone) films using acrylic acid and collagen
dc.contributor.authorCheng, Z.
dc.contributor.authorTeoh, S.-H.
dc.date.accessioned2014-06-17T06:35:03Z
dc.date.available2014-06-17T06:35:03Z
dc.date.issued2004-05
dc.identifier.citationCheng, Z., Teoh, S.-H. (2004-05). Surface modification of ultra thin poly (ε-caprolactone) films using acrylic acid and collagen. Biomaterials 25 (11) : 1991-2001. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2003.08.038
dc.identifier.issn01429612
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/61431
dc.description.abstractPoly (ε-caprolactone) (PCL) has been used as a bioresorbable polymer in numerous medical devices as well as for tissue engineering applications. Its main advantage is its biocompatibility and slow degradation rate. PCL surface, however, is hydrophobic and cell-biomaterial interaction is not the best. We attempt for the first time to modify an ultra thin PCL surface with collagen. The PCL film was prepared using solvent casting and biaxial stretching technique developed in our laboratory. This biaxial stretching produced an ultra thin PCL 3-7μm thick, ideal for membrane tissue engineering applications. The PCL film was pretreated using Argon plasma, and then UV polymerized with acrylic acid (AAc). Collagen immobilization was then carried out. The modified film surface was characterized by Fourier Transform Infrared (FT-IR) and X-ray Photoelectron Spectroscopy (XPS). Water contact angles were also measured to evaluate the hydrophilicity of the modified surface. Results showed that the hydrophilicity of the surface has improved significantly after surface modification. The water contact angle dropped from 66° to 32°. Atomic Force Microscopy (AFM) showed an increase in roughness of the film. A change from 46 to 60nm in the surface morphology was also observed. The effect of cells attachment on the PCL film was studied. Human dermal fibroblasts and myoblasts attachment and proliferation were improved remarkably on the modified surface. The films showed excellent cell attachment and proliferation rate. © 2003 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biomaterials.2003.08.038
dc.sourceScopus
dc.subjectCollagen immobilization
dc.subjectHuman dermal fibroblasts
dc.subjectMyoblasts
dc.subjectPoly (ε-caprolactone)
dc.subjectSurface modification
dc.typeArticle
dc.contributor.departmentOPHTHALMOLOGY
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.1016/j.biomaterials.2003.08.038
dc.description.sourcetitleBiomaterials
dc.description.volume25
dc.description.issue11
dc.description.page1991-2001
dc.description.codenBIMAD
dc.identifier.isiut000188796600003
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