1. ScholarBank@NUS
  2. 1. Staff
  3. Staff Publications
Please use this identifier to cite or link to this item: https://doi.org/10.1002/mabi.201200391
DC FieldValue
dc.titleMimicking Native Extracellular Matrix with Phytic Acid-Crosslinked Protein Nanofibers for Cardiac Tissue Engineering
dc.contributor.authorRavichandran, R.
dc.contributor.authorSeitz, V.
dc.contributor.authorReddy Venugopal, J.
dc.contributor.authorSridhar, R.
dc.contributor.authorSundarrajan, S.
dc.contributor.authorMukherjee, S.
dc.contributor.authorWintermantel, E.
dc.contributor.authorRamakrishna, S.
dc.date.accessioned2014-06-17T06:27:06Z
dc.date.available2014-06-17T06:27:06Z
dc.date.issued2013-03
dc.identifier.citationRavichandran, R., Seitz, V., Reddy Venugopal, J., Sridhar, R., Sundarrajan, S., Mukherjee, S., Wintermantel, E., Ramakrishna, S. (2013-03). Mimicking Native Extracellular Matrix with Phytic Acid-Crosslinked Protein Nanofibers for Cardiac Tissue Engineering. Macromolecular Bioscience 13 (3) : 366-375. ScholarBank@NUS Repository. https://doi.org/10.1002/mabi.201200391
dc.identifier.issn16165187
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/60768
dc.description.abstractA functional scaffold fabricated is developed from natural polymers, favoring regeneration of the ischemic myocardium. Hemoglobin/gelatin/fibrinogen (Hb/gel/fib) nanofibers are fabricated by electrospinning and are characterized for morphology, scaffold composition, functional groups and hydrophilicity. It is hypothesized that ex vivo pretreatment of mesenchymal stem cells (MSCs) using 5-azacytidine and such a functional nanofibrous construct having a high oxygen-carrying potential could lead to enhanced cardiomyogenic differentiation of MSCs and result in superior biological and functional effects. The combination of a functional nanofibrous scaffold composed of natural polymers and crosslinked with a natural crosslinking agent, phytic acid, and stem cell biology may prove to be a novel therapeutic device for treatment of myocardial infarction. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/mabi.201200391
dc.sourceScopus
dc.subjectCardiogenic differentiation
dc.subjectCrosslinkers
dc.subjectIschemic myocardium
dc.subjectMesenchymal stem cells
dc.subjectPhytic acid
dc.typeArticle
dc.contributor.departmentMECHANICAL ENGINEERING
dc.contributor.departmentNUS NANOSCIENCE & NANOTECH INITIATIVE
dc.description.doi10.1002/mabi.201200391
dc.description.sourcetitleMacromolecular Bioscience
dc.description.volume13
dc.description.issue3
dc.description.page366-375
dc.description.codenMBAIB
dc.identifier.isiut000316627800011
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.