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Title: Biomimetic hydroxyapatite-containing composite nanofibrous substrates for bone tissue engineering
Authors: Venugopal, J. 
Prabhakaran, M.P. 
Zhang, Y. 
Low, S.
Choon, A.T.
Ramakrishna, S. 
Keywords: Bone tissue engineering
Synthetic and natural polymers
Issue Date: 28-Apr-2010
Citation: Venugopal, J., Prabhakaran, M.P., Zhang, Y., Low, S., Choon, A.T., Ramakrishna, S. (2010-04-28). Biomimetic hydroxyapatite-containing composite nanofibrous substrates for bone tissue engineering. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 368 (1917) : 2065-2081. ScholarBank@NUS Repository.
Abstract: The fracture of bones and large bone defects owing to various traumas or natural ageing is a typical type of tissue malfunction. Surgical treatment frequently requires implantation of a temporary or permanent prosthesis, which is still a challenge for orthopaedic surgeons, especially in the case of large bone defects. Mimicking nanotopography of natural extracellular matrix (ECM) is advantageous for the successful regeneration of damaged tissues or organs. Electrospun nanofibre-based synthetic and natural polymer scaffolds are being explored as a scaffold similar to natural ECM for tissue engineering applications. Nanostructured materials are smaller in size falling, in the 1-100nm range, and have specific properties and functions related to the size of the natural materials (e.g. hydroxyapatite (HA)). The development of nanofibres with nano-HA has enhanced the scope of fabricating scaffolds to mimic the architecture of natural bone tissue. Nanofibrous substrates supporting adhesion, proliferation, differentiation of cells and HA induce the cells to secrete ECM for mineralization to form bone in bone tissue engineering. Our laboratory (NUSNNI, NUS) has been fabricating a variety of synthetic and natural polymer-based nanofibrous substrates and synthesizing HA for blending and spraying on nanofibres for generating artificial ECM for bone tissue regeneration. The present review is intended to direct the reader's attention to the important subjects of synthetic and natural polymers with HA for bone tissue engineering. © 2010.
Source Title: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
ISSN: 1364503X
DOI: 10.1098/rsta.2010.0012
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