Please use this identifier to cite or link to this item: https://doi.org/10.1002/aic.11858
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dc.titleA fine match between the stereoselective ligands and membrane pore size for enhanced chiral separation
dc.contributor.authorWang, H.
dc.contributor.authorLi, Y.
dc.contributor.authorChung, T.-S.
dc.date.accessioned2014-06-16T09:27:58Z
dc.date.available2014-06-16T09:27:58Z
dc.date.issued2009-09
dc.identifier.citationWang, H., Li, Y., Chung, T.-S. (2009-09). A fine match between the stereoselective ligands and membrane pore size for enhanced chiral separation. AIChE Journal 55 (9) : 2284-2291. ScholarBank@NUS Repository. https://doi.org/10.1002/aic.11858
dc.identifier.issn00011541
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/54146
dc.description.abstractA D,L-tryptophan separation factor of 12-15 and D-tryptophan yield of >95% have been successfully achieved through using human serum albumin (HSA) as the stereoselective ligand in an affinity ultrafiltration (UF) system. The obtained separation factor in this work is even higher than the intrinsic value of 8.5 of HSA. This synergism may arise from the fact that a fine match between the regular crystalline structure of HSA molecules and suitable pore size of membranes makes some HSA molecules be retained within the membrane cross-section, thus offering a second-stage binding opportunity for L-tryptophan molecules. Therefore, a simultaneous enhancement in separation factor and D-tryptophan yield has been fulfilled in this work. The feasibility of HSA regeneration after D,L-tryptophan separation has also been demonstrated through a series of pH adjustment experiments. This study reveals the applicability of HSA in affinity UF systems for chiral separation due to economization of material costs. © 2009 American Institute of Chemical Engineers.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/aic.11858
dc.sourceScopus
dc.subjectAffinity ultrafiltration
dc.subjectChiral separation
dc.subjectMembrane pore size
dc.subjectSerum albumin
dc.subjectStereoselective ligand
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1002/aic.11858
dc.description.sourcetitleAIChE Journal
dc.description.volume55
dc.description.issue9
dc.description.page2284-2291
dc.description.codenAICEA
dc.identifier.isiut000269134700009
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