Please use this identifier to cite or link to this item: https://doi.org/10.1097/HJH.0b013e328362c201
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dc.titleRetinal vascular fractal and blood pressure in a multiethnic population
dc.contributor.authorSng, C.C.A.
dc.contributor.authorWong, W.L.
dc.contributor.authorCheung, C.Y.
dc.contributor.authorLee, J.
dc.contributor.authorTai, E.S.
dc.contributor.authorWong, T.Y.
dc.date.accessioned2014-05-20T02:30:17Z
dc.date.available2014-05-20T02:30:17Z
dc.date.issued2013-10
dc.identifier.citationSng, C.C.A., Wong, W.L., Cheung, C.Y., Lee, J., Tai, E.S., Wong, T.Y. (2013-10). Retinal vascular fractal and blood pressure in a multiethnic population. Journal of Hypertension 31 (10) : 2036-2042. ScholarBank@NUS Repository. https://doi.org/10.1097/HJH.0b013e328362c201
dc.identifier.issn02636352
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/53489
dc.description.abstractObjective(s): To examine the effect of blood pressure (BP) on retinal vascular fractal dimension (Df), a measure of microvascular network complexity and density in a multiethnic cohort. Methods: A population-based study of 3876 Chinese, Malay and Indian participants in Singapore. Retinal Df was measured using a computer-based program from digital retinal photographs. Associations between retinal Df and mean arterial BP (MABP) in the whole cohort and in each racial group were analysed using linear regression analysis. Logistic regression was used to examine the association between retinal Df and hypertension status. Results: The mean retinal Df of the study population was 1.45 (standard deviation 0.03). After adjustment for age, sex, race, diabetes, BMI, cholesterol and creatinine levels, persons with smaller Df had higher MABP (mean difference MABP was 6.18mmHg comparing lowest to highest Df quartiles, P<0.001). This was similar in Chinese, Malay and Indian persons [mean difference 6.40 (P<0.001), 4.72 (P=0.011) and 6.62 (P<0.001) mmHg, respectively]. Persons with smaller retinal Df were more likely to have uncontrolled treated or untreated hypertension [odds ratio 1.79 (P=0.003) and 2.60 (P=0.003), respectively, comparing lowest to highest Df quartiles] than those with no hypertension; this relationship was not seen comparing persons with controlled treated hypertension with no hypertension (odds ratio 1.01, P=0.972). Conclusion: Hypertension was associated with a sparser retinal vascular network, which was similar across different racial/ethnic groups and most apparent in those with uncontrolled or untreated hypertension. These data suggest that microvascular remodelling can be quantified by measuring retinal vasculature. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1097/HJH.0b013e328362c201
dc.sourceScopus
dc.subjectBlood pressure
dc.subjectFractal
dc.subjectHypertension
dc.subjectRetinal vasculature
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1097/HJH.0b013e328362c201
dc.description.sourcetitleJournal of Hypertension
dc.description.volume31
dc.description.issue10
dc.description.page2036-2042
dc.description.codenJOHYD
dc.identifier.isiut000326589700018
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