Please use this identifier to cite or link to this item:
https://doi.org/10.1016/S0891-5849(02)01436-3
DC Field | Value | |
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dc.title | Expression of major HDL-associated antioxidant PON-1 is gender dependent and regulated during inflammation | |
dc.contributor.author | Ali, A.B. | |
dc.contributor.author | Zhang, Q. | |
dc.contributor.author | Lim, Y.K. | |
dc.contributor.author | DONG FANG | |
dc.contributor.author | Retnam, L. | |
dc.contributor.author | Lim, S.-K. | |
dc.date.accessioned | 2014-05-20T02:29:20Z | |
dc.date.available | 2014-05-20T02:29:20Z | |
dc.date.issued | 2003-04-01 | |
dc.identifier.citation | Ali, A.B., Zhang, Q., Lim, Y.K., DONG FANG, Retnam, L., Lim, S.-K. (2003-04-01). Expression of major HDL-associated antioxidant PON-1 is gender dependent and regulated during inflammation. Free Radical Biology and Medicine 34 (7) : 824-829. ScholarBank@NUS Repository. https://doi.org/10.1016/S0891-5849(02)01436-3 | |
dc.identifier.issn | 08915849 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/53430 | |
dc.description.abstract | Paraoxonase 1, an HDL-associated enzyme that confers antioxidant activity on HDL, and its activity in serum have been correlated with protection against atherosclerosis, an oxidative disease. However, serum PON-1 activity is highly variable and its regulation is complex, involving both genetic and environmental factors. It is influenced by gender and inflammation, two important factors in atherosclerosis. Serum PON-1 activity has been shown to be lower in male mice and is decreased in male Syrian hamster during inflammation. Here we show that male mice had lower hepatic PON-1 mRNA that increased by 170% after castration. Our data also suggested that this effect was testes but not plasma testosterone dependent. Ovariectomy had no effect on PON-1 mRNA in female mice. LPS caused hepatic PON-1 mRNA to decrease further in male mice, and to increase moderately in female mice. Anti-inflammatory dexamethasone enhanced PON-1 mRNA level by 2-fold in male and female LPS-treated mice, and increased PON-1 expression by 8-fold in Hepa cell, a mouse hepatoma cell line. Therefore, antioxidant PON-1 is regulated at the mRNA level in a gender-specific manner by proinflammatory LPS and anti-inflammatory dexamethasone. © 2003 Elsevier Science Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0891-5849(02)01436-3 | |
dc.source | Scopus | |
dc.subject | Antioxidant | |
dc.subject | Free radicals | |
dc.subject | Gender | |
dc.subject | HDL | |
dc.subject | Inflammation | |
dc.subject | Paraoxonase 1 | |
dc.type | Article | |
dc.contributor.department | GENOME INSTITUTE OF SINGAPORE | |
dc.contributor.department | NATIONAL UNIVERSITY MEDICAL INSTITUTES | |
dc.contributor.department | SURGERY | |
dc.description.doi | 10.1016/S0891-5849(02)01436-3 | |
dc.description.sourcetitle | Free Radical Biology and Medicine | |
dc.description.volume | 34 | |
dc.description.issue | 7 | |
dc.description.page | 824-829 | |
dc.description.coden | FRBME | |
dc.identifier.isiut | 000181735200005 | |
Appears in Collections: | Staff Publications |
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