Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.neurobiolaging.2013.04.012
| Title: | Absence of A673T amyloid-β precursor protein variant in alzheimer's disease and other neurological diseases | Authors: | Ting, S.K.S. Chong, M.-S. Kandiah, N. Hameed, S. Tan, L. Au, W.-L. Prakash, K.M. Pavanni, R. Lee, T.-S. Foo, J.-N. Bei, J.-X. Yu, X.-Q. Liu, J.-J. Zhao, Y. Lee, W.-L. Tan, E.-K. |
Keywords: | A673T Amyloid-beta precursor protein Dementia |
Issue Date: | Oct-2013 | Citation: | Ting, S.K.S., Chong, M.-S., Kandiah, N., Hameed, S., Tan, L., Au, W.-L., Prakash, K.M., Pavanni, R., Lee, T.-S., Foo, J.-N., Bei, J.-X., Yu, X.-Q., Liu, J.-J., Zhao, Y., Lee, W.-L., Tan, E.-K. (2013-10). Absence of A673T amyloid-β precursor protein variant in alzheimer's disease and other neurological diseases. Neurobiology of Aging 34 (10) : 2441e7-2441e8. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2013.04.012 | Abstract: | The rare variant A673T in the amyloid-β precursor protein (APP) gene has been shown to reduce the risk of cognitive impairment. We genotyped the variant in 8721 Asian individuals comprising 552 with Alzheimer's disease and vascular dementia, 790 with Parkinson's disease, and 7379 controls. The A673T variant was absent in all of the subjects. Our finding suggests that the A673T protective variant is not relevant in our Asian population. Studies in other ethnic populations would clarify whether this variant is specific to specific races/ethnicities. © 2013. | Source Title: | Neurobiology of Aging | URI: | http://scholarbank.nus.edu.sg/handle/10635/53391 | ISSN: | 01974580 | DOI: | 10.1016/j.neurobiolaging.2013.04.012 |
| Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.