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|Title:||Amine-catalyzed [3+2] Huisgen cycloaddition strategy for the efficient assembly of highly substituted 1,2,3-triazoles||Authors:||Wang, L.
|Issue Date:||7-May-2012||Citation:||Wang, L., Peng, S., Danence, L.J.T., Gao, Y., Wang, J. (2012-05-07). Amine-catalyzed [3+2] Huisgen cycloaddition strategy for the efficient assembly of highly substituted 1,2,3-triazoles. Chemistry - A European Journal 18 (19) : 6088-6093. ScholarBank@NUS Repository. https://doi.org/10.1002/chem.201103393||Abstract:||An enamine-catalyzed strategy has been utilized to fully promote the Huisgen [3+2] cycloaddition with a broad spectrum of carbonyl compounds and azides, thereby permitting the efficient assembly of a vast pool of highly substituted 1,2,3-triazoles. In particular, the employment of commonly used and commercially available carbonyl compounds has resulted in the introduction of a diverse set of functional groups, such as alkyl, aryl, nitrile, ester, and ketone groups, at the 1-, 4-, or 5-positions of the 1,2,3-triazole scaffold. This approach might be manipulated to access more useful and sophisticated heterocyclic compounds. Most significantly, the reaction process exhibits complete regioselectivity, with the formation of only one regioisomer. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.||Source Title:||Chemistry - A European Journal||URI:||http://scholarbank.nus.edu.sg/handle/10635/52777||ISSN:||09476539||DOI:||10.1002/chem.201103393|
|Appears in Collections:||Staff Publications|
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