Please use this identifier to cite or link to this item: https://doi.org/10.1016/0021-9673(93)83007-F
DC FieldValue
dc.titlePreparative resolution of praziquantel enantiomers by simulated counter-current chromatography
dc.contributor.authorChing, C.B.
dc.contributor.authorLim, B.G.
dc.contributor.authorLee, E.J.D.
dc.contributor.authorNg, S.C.
dc.date.accessioned2014-05-16T07:36:57Z
dc.date.available2014-05-16T07:36:57Z
dc.date.issued1993
dc.identifier.citationChing, C.B., Lim, B.G., Lee, E.J.D., Ng, S.C. (1993). Preparative resolution of praziquantel enantiomers by simulated counter-current chromatography. Journal of Chromatography 634 (2) : 215-219. ScholarBank@NUS Repository. https://doi.org/10.1016/0021-9673(93)83007-F
dc.identifier.issn00219673
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/52714
dc.description.abstractThe continuous chromatographic separation of a racemic anthelmintic drug, praziquantel, was carried out using a simulated counter-current system. The system consists of four identical columns (445 mm x 12.5 mm I.D.) connected in series through solenoid valves. The chiral stationary phase used is microcrystalline cellulose triacetate and the eluent is methanol. Feed at 50 mg/ml was continuously introduced into the system at 0.3 ml/min and 429 mg/h of (+)-praziquantel and 404 mg/h of (-)-praziquantel were obtained from the extract and raffinate streams, respectively. The optical purity of the products was more than 90%. This method provides an extremely useful technique for preparative-scale enantioseparation. Compared with conventional batch preparative-scale processes, this system offers a higher solute to adsorbent mass ratio.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/0021-9673(93)83007-F
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.contributor.departmentCHEMICAL ENGINEERING
dc.description.doi10.1016/0021-9673(93)83007-F
dc.description.sourcetitleJournal of Chromatography
dc.description.volume634
dc.description.issue2
dc.description.page215-219
dc.description.codenJOCRA
dc.identifier.isiutA1993KV48200007
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

83
checked on May 23, 2022

WEB OF SCIENCETM
Citations

73
checked on May 23, 2022

Page view(s)

155
checked on May 12, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.