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Title: | GALECTIN 3 EXPRESSION AND ITS ROLE IN HOST RESPONSE TO THE PATHOGENESIS OF HELICOBACTER PYLORI | Authors: | VINOD VIJAYASUBHASH | Keywords: | H. pylori, Galectin-3, inflammation, proliferation | Issue Date: | 23-Aug-2013 | Citation: | VINOD VIJAYASUBHASH (2013-08-23). GALECTIN 3 EXPRESSION AND ITS ROLE IN HOST RESPONSE TO THE PATHOGENESIS OF HELICOBACTER PYLORI. ScholarBank@NUS Repository. | Abstract: | Helicobacter pylori is a major etiological agent which is strongly associated with the risk of developing peptic ulcer disease and gastric cancer. Galectin-3 (Gal-3) is a multifunctional ?-galactoside lectin which is widely expressed in gastric epithelial cells. Gal-3 is upregulated and rapidly secreted as a host response to H. pylori infection. The current study characterizes the cellular dynamics; expression as well as functional roles of Gal-3 in modulating crucial host responses in H. pylori infected gastric epithelial cells. In this study, Gal-3 was found to be upregulated and exported from the nucleus to the cytoplasm in H. pylori-infected gastric epithelial cells. More over Gal-3 was found to modulate the inflammatory and proliferative response during H. pylori infection by interfering with various intercellular signalling pathways. | URI: | http://scholarbank.nus.edu.sg/handle/10635/52361 |
Appears in Collections: | Ph.D Theses (Open) |
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FINAL THESIS_2014_NUS.pdf | 7.16 MB | Adobe PDF | OPEN | None | View/Download |
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