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https://scholarbank.nus.edu.sg/handle/10635/52361
DC Field | Value | |
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dc.title | GALECTIN 3 EXPRESSION AND ITS ROLE IN HOST RESPONSE TO THE PATHOGENESIS OF HELICOBACTER PYLORI | |
dc.contributor.author | VINOD VIJAYASUBHASH | |
dc.date.accessioned | 2014-05-14T18:00:28Z | |
dc.date.available | 2014-05-14T18:00:28Z | |
dc.date.issued | 2013-08-23 | |
dc.identifier.citation | VINOD VIJAYASUBHASH (2013-08-23). GALECTIN 3 EXPRESSION AND ITS ROLE IN HOST RESPONSE TO THE PATHOGENESIS OF HELICOBACTER PYLORI. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/52361 | |
dc.description.abstract | Helicobacter pylori is a major etiological agent which is strongly associated with the risk of developing peptic ulcer disease and gastric cancer. Galectin-3 (Gal-3) is a multifunctional ?-galactoside lectin which is widely expressed in gastric epithelial cells. Gal-3 is upregulated and rapidly secreted as a host response to H. pylori infection. The current study characterizes the cellular dynamics; expression as well as functional roles of Gal-3 in modulating crucial host responses in H. pylori infected gastric epithelial cells. In this study, Gal-3 was found to be upregulated and exported from the nucleus to the cytoplasm in H. pylori-infected gastric epithelial cells. More over Gal-3 was found to modulate the inflammatory and proliferative response during H. pylori infection by interfering with various intercellular signalling pathways. | |
dc.language.iso | en | |
dc.subject | H. pylori, Galectin-3, inflammation, proliferation | |
dc.type | Thesis | |
dc.contributor.department | MICROBIOLOGY | |
dc.contributor.supervisor | HO BOW | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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FINAL THESIS_2014_NUS.pdf | 7.16 MB | Adobe PDF | OPEN | None | View/Download |
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