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Title: The effect of Rhbmp-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds
Authors: Rai, B.
Teoh, S.H. 
Ho, K.H. 
Chen, F.
Kamal, Y.
Hutmacher, D. 
Tong, C. 
Issue Date: 2004
Citation: Rai, B.,Teoh, S.H.,Ho, K.H.,Chen, F.,Kamal, Y.,Hutmacher, D.,Tong, C. (2004). The effect of Rhbmp-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds. Transactions - 7th World Biomaterials Congress : 589-. ScholarBank@NUS Repository.
Abstract: The effect of human recombinant bone morphogenetic protein-2 (rhBMP-2) on canine osteoblasts seeded onto three dimensional bioactive polycaprolactone 20% tricalcium phosphate (PCL-TCP) scaffolds was investigated. Canine osteoblasts, rhBMP-2 of various concentrations and fibrin glue were simultaneously seeded onto the top of the porous scaffolds which were placed in 24-well culture plates. It was observed that rhBMP-2 enhanced the differentiated function of canine osteoblasts in a non-dose dependent manner, which resulted in accelerated mineralization, followed by death of osteoblasts as they underwent terminal differentiation. PCL-TCP scaffolds seeded only with canine osteoblasts was found to sustain excellent osteogenic expression in vitro.
Source Title: Transactions - 7th World Biomaterials Congress
ISBN: 1877040193
Appears in Collections:Staff Publications

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