Please use this identifier to cite or link to this item: https://doi.org/10.1177/0961203312471872
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dc.titleSerum tumour necrosis factor-alpha is associated with poor health-related quality of life and depressive symptoms in patients with systemic lupus erythematosus
dc.contributor.authorMak, A.
dc.contributor.authorTang, C.S.
dc.contributor.authorHo, R.C.
dc.date.accessioned2014-04-03T05:20:55Z
dc.date.available2014-04-03T05:20:55Z
dc.date.issued2013-03
dc.identifier.citationMak, A., Tang, C.S., Ho, R.C. (2013-03). Serum tumour necrosis factor-alpha is associated with poor health-related quality of life and depressive symptoms in patients with systemic lupus erythematosus. Lupus 22 (3) : 254-261. ScholarBank@NUS Repository. https://doi.org/10.1177/0961203312471872
dc.identifier.issn09612033
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/49970
dc.description.abstractObjectives: While patients with systemic lupus erythematosus (SLE) have poorer healthrelated quality of life (HRQoL) and are more depressed than healthy people, the impact of proinflammatory cytokines, particularly tumour necrosis factor-alpha (TNFα), on these unfavourable psychosocial parameters is unclear. We aim to explore potential relationships between lupus-related proinflammatory cytokines, HRQoL and depressive symptoms in patients with SLE. Methods: Patients with SLE and age-matched healthy subjects were assessed for HRQoL and depressive and anxiety symptoms by the Short Form Health Survey-36 (SF-36) and Hospital Anxiety and Depression Scale (HADS) respectively. Using multiplex immunoassay, a panel of serum proinflammatory cytokines including TNFα, interleukin (IL)-1β, IL-6, IL-17, IL-23 and IL-33 were determined and compared between both groups. Independent associations between SF-36, serum proinflammatory cytokine levels and HADS scores were studied by regression models. Results: In total, 54 patients and 54 healthy controls were studied. Lupus patients had significantly poorer HRQoL (p<0.001) and were significantly more depressed (p=0.006) and anxious (p=0.022) than their healthy counterparts. Amongst the proinflammatory cytokines studied, serum TNFα was significantly higher in lupus patients (p<0.001). After multivariate adjustment, higher serum TNFα (β=-0.224, p=0.047) remained significantly associated with lower SF-36, along with smoking (β=-0.253, p=0.014) and more severe depressive symptoms (b=-0.433, p=0.002). In healthy subjects, serum TNFα was associated with depressive symptoms but not with SF- 36. Conclusions: Higher serum TNFα level is independently associated with poorer HRQoL and more severe depressive symptoms in SLE patients. These associations suggest a potential impact of inflammatory response on depressive symptoms and the quality of life in patients with SLE. Lupus (2013) 22, 254261.© The Author(s), 2012.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1177/0961203312471872
dc.sourceScopus
dc.subjectdepression
dc.subjecthealth-related quality of life
dc.subjectProinflammatory cytokines
dc.subjectsystemic lupus erythematosus
dc.subjecttumour necrosis factor alpha
dc.typeArticle
dc.contributor.departmentPSYCHOLOGY
dc.contributor.departmentMEDICINE
dc.contributor.departmentPSYCHOLOGICAL MEDICINE
dc.description.doi10.1177/0961203312471872
dc.description.sourcetitleLupus
dc.description.volume22
dc.description.issue3
dc.description.page254-261
dc.description.codenLUPUE
dc.identifier.isiut000317339200005
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