Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.freeradbiomed.2004.03.017
DC FieldValue
dc.titleCharacterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional chinese medicines
dc.contributor.authorTang, S.Y.
dc.contributor.authorWhiteman, M.
dc.contributor.authorPeng, Z.F.
dc.contributor.authorJenner, A.
dc.contributor.authorYong, E.L.
dc.contributor.authorHalliwell, B.
dc.date.accessioned2013-04-10T04:41:14Z
dc.date.available2013-04-10T04:41:14Z
dc.date.issued2004
dc.identifier.citationTang, S.Y., Whiteman, M., Peng, Z.F., Jenner, A., Yong, E.L., Halliwell, B. (2004). Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional chinese medicines. Free Radical Biology and Medicine 36 (12) : 1575-1587. ScholarBank@NUS Repository. https://doi.org/10.1016/j.freeradbiomed.2004.03.017
dc.identifier.issn08915849
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/37401
dc.description.abstractThere is considerable interest in the isolation of more potent antioxidant compounds to treat diseases involving oxidative stress. Thirty-three traditional Chinese medicine (TCM) extracts were examined for their antioxidant activity using the 2,2′-azinobis[3-ethylbenzothiazoline-6-sulfonate] (ABTS) assay. Five extracts with high activity (Cratoxylum cochinchinense, Cortex magnoliae officinalis, Psoralea corylifolia L, Curculigo orchioides Gaertn, and Glycyrrhiza uralensis Fisch.) were selected for further characterization. C. cochinchinense outperformed other extracts in most of the assays tested except phospholipid peroxidation inhibition, where P. corylifolia L showed higher activity. C. cochinchinense was particularly potent in inhibiting the formation of advanced glycation end products on proteins and strongly inhibited hypochlorous acid-induced DNA damage. We attempted to isolate the active ingredients from C. cochinchinense and obtained an extract (YCT) containing at least 90% mangiferin as identified by HPLC and mass spectrometry. However, YCT showed significantly higher activity in assays of phospholipid peroxidation, inhibition of protein glycation, and superoxide (O2·-) and peroxynitrite (ONOO-) scavenging, as compared with mangiferin, suggesting that the nonmangiferin constituents of YCT contribute to its additional antioxidant activities. © 2004 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.freeradbiomed.2004.03.017
dc.sourceScopus
dc.subject2,2′-azinobis[3-ethylbenzothiazoline-6- sulfonate]
dc.subject3-nitrotyrosine
dc.subjectABTS
dc.subjectAdvanced glycation end products
dc.subjectAGE
dc.subjectCratoxylum cochinchinense
dc.subjectDNA damage
dc.subjectFree radicals
dc.subjectLipid peroxidation
dc.subjectMangiferin
dc.subjectPeroxynitrite
dc.subjectTraditional Chinese medicine
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.freeradbiomed.2004.03.017
dc.description.sourcetitleFree Radical Biology and Medicine
dc.description.volume36
dc.description.issue12
dc.description.page1575-1587
dc.description.codenFRBME
dc.identifier.isiut000222233000010
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

141
checked on Jun 20, 2022

WEB OF SCIENCETM
Citations

121
checked on Sep 28, 2021

Page view(s)

243
checked on Jun 23, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.