Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0029-7844(99)00272-0
DC FieldValue
dc.titleEvacuation interval after vaginal misoprostol for preabortion cervical priming: A randomized trial
dc.contributor.authorSingh, K.
dc.contributor.authorFong, Y.F.
dc.contributor.authorPrasad, R.N.V.
dc.contributor.authorDong, F.
dc.date.accessioned2013-04-10T04:40:50Z
dc.date.available2013-04-10T04:40:50Z
dc.date.issued1999
dc.identifier.citationSingh, K., Fong, Y.F., Prasad, R.N.V., Dong, F. (1999). Evacuation interval after vaginal misoprostol for preabortion cervical priming: A randomized trial. Obstetrics and Gynecology 94 (3) : 431-434. ScholarBank@NUS Repository. https://doi.org/10.1016/S0029-7844(99)00272-0
dc.identifier.issn00297844
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/37378
dc.description.abstractObjective: To determine the optimal interval for evacuation after preabortion cervical priming with vaginal misoprostol. Methods: One hundred eighty healthy nulliparas requesting legal termination of pregnancy between 6 and 11 weeks' gestation were assigned randomly to receive 400, 600, or 800 μg of intravaginal misoprostol. Vacuum aspiration was done after 3 hours in the 400-μg group and after 2 hours in the 600- and 800-μg groups. The degree of cervical dilatation before operation was measured with a Hegar dilator. Preoperative and intraoperative blood loss and associated side effects were also assessed. Results: Eleven (18.3%) and 15 (25.0%) women in the 600- and 800-μg groups, respectively, had cervical dilatation of at least 8 mm after an interval of 2 hours; 55 (91.7%) women who received 400 μg for a 3-hour interval had similar cervical dilatation. Using 400 μg as a baseline, the odds ratio (OR) was 0.02; 95% confidence interval (CI) was 0.01, 0.06 for 600 μg and OR 0.03; 95% CI 0.01, 0.09 for 800 μg for achieving successful preabortion cervical dilatation of at least 8 mm. The mean cervical dilatation of 6.7 mm and 6.8 mm for the higher doses was also significantly less than that of 8.1 for the 400-μg dose (P < .001). The mean preoperative and intraoperative blood loss was only statistically different when the 400- and 800-μg groups were compared (P = .03). There were also significantly more side effects, namely abdominal pain and fever above 38.0C, in the 600- and 800-μg groups (P < .001), compared with the 400-μg group. When the 600- and 800-μg groups were compared, there were still significantly more women complaining of abdominal pain (P < .001). None of the women in the study required analgesics for pain or antipyretics for fever. Conclusion: The minimal evacuation interval should be at least 3 hours for successful preabortion cervical priming. Copyright (C) 1999 The American College of Obstetricians and Gynecologists.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0029-7844(99)00272-0
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentNATIONAL UNIVERSITY MEDICAL INSTITUTES
dc.description.doi10.1016/S0029-7844(99)00272-0
dc.description.sourcetitleObstetrics and Gynecology
dc.description.volume94
dc.description.issue3
dc.description.page431-434
dc.description.codenOBGNA
dc.identifier.isiut000082249100021
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