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Title: Effect of Norplant®-2 rods on liver, lipid and carbohydrate metabolism
Authors: Singh, K. 
Viegas, O.A.C. 
Loke, D. 
Ratnam, S.S. 
Issue Date: 1992
Citation: Singh, K., Viegas, O.A.C., Loke, D., Ratnam, S.S. (1992). Effect of Norplant®-2 rods on liver, lipid and carbohydrate metabolism. Contraception 45 (5) : 463-472. ScholarBank@NUS Repository.
Abstract: The effect of Norplant®-2 rods on liver, lipid and carbohydrate metabolism was evaluated in 100 women using Norplant®-2 rods. Besides a significant increase in serum bilirubin, there was no other obvious evidence to suggest any possible hepatocellular dysfunction with the use of Norplant®-2 rods. As regards lipid metabolism, decreases in total triglycerides, cholesterol and LDL-cholesterol and HDL-cholesterol were initially seen. These parameters returned to their preinsertion mean at the end of five years. As a result, the value of the HDL-cholesterol/total cholesterol - HDL-cholesterol and LDL-cholesterol/HDL-cholesterol ratios remained around their preinsertion value at the end of five years. All this appears to indicate that the use of Norplant®-2 rods is not directly contributory to cardiovascular risk. The use of Norplant®-2 rods was not associated with any significant effect on carbohydrate metabolism.
Source Title: Contraception
ISSN: 00107824
DOI: 10.1016/0010-7824(92)90159-Q
Appears in Collections:Staff Publications

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