Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/34877
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dc.titleSUSHI PEPTIDE MULTIMER
dc.contributorNATIONAL UNIVERSITY OF SINGAPORE
dc.contributor.authorDING, JEAK LING
dc.contributor.authorHO, BOW
dc.date.accessioned2012-10-05T06:01:48Z
dc.date.available2012-10-05T06:01:48Z
dc.date.issued2006-04-12
dc.identifier.citationDING, JEAK LING,HO, BOW (2006-04-12). SUSHI PEPTIDE MULTIMER. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/34877
dc.description.abstractEndotoxin, also known as lipopolysaccharides (LPS), is the major mediator of septic shock due to Gram-negative bacterial infection. Chemically synthesized S3 peptide, derived from Sushi3 domain of Factor C, which is the endotoxin-sensitive serine protease of the limulus coagulation cascade, binds and neutralizes LPS activity. Fluorescent tagged-S3 is shown to detect LPS-containing bacteria. For large-scale production of S3 and to mimick other pathogen-recognizing molecules, tandem multimers of the S3 gene were constructed and expressed in E. coli. Tetramer of S3 for example is shown to display an enhanced inhibitory effect on LPS-induced activities. An affinity matrix based on tetramer of S3 is also shown to be particularly efficient at removing LPS.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/http://analytics.patsnap.com/patent_view/view?pn=EP1644410A1
dc.sourcePatSnap
dc.typePatent
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentMICROBIOLOGY
dc.identifier.isiutNOT_IN_WOS
dc.description.patentnoEP1644410A1
dc.description.patenttypePublished Application
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