Please use this identifier to cite or link to this item:
https://doi.org/10.1016/S0003-9861(02)00447-2
DC Field | Value | |
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dc.title | A novel prothrombin activator from the venom of Micropechis ikaheka: Isolation and characterization | |
dc.contributor.author | Gao, R. | |
dc.contributor.author | Gopalakrishnakone, P. | |
dc.contributor.author | Kini, R.M. | |
dc.date.accessioned | 2012-06-08T09:30:58Z | |
dc.date.available | 2012-06-08T09:30:58Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | Gao, R., Gopalakrishnakone, P., Kini, R.M. (2002). A novel prothrombin activator from the venom of Micropechis ikaheka: Isolation and characterization. Archives of Biochemistry and Biophysics 408 (1) : 87-92. ScholarBank@NUS Repository. https://doi.org/10.1016/S0003-9861(02)00447-2 | |
dc.identifier.issn | 00039861 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/33904 | |
dc.description.abstract | A novel prothrombin activator, Mikarin, has been isolated from Micropechis ikaheka venom. It is a single polypeptide chain metalloproteinase with the apparent molecular weight of 47 kDa. Mikarin exhibits Ca2+-independent prothrombin activation, but no effects on other blood coagulation factors, such as factor X and fibrinogen. Mikarin is the first member of group I prothrombin activators from elapid venom. Like other high-molecular-weight snake venom proteinases, it has three structural domains, metalloproteinase and disintegrin-like and Cys-rich domains, and belongs to the P-III class of snake venom metalloproteinases. The N-terminal of Mikarin exhibits 76% sequence identity with Cobrin, a metalloproteinase identified from Naja naja venom, but very lower identities were found when compared with those from viperid and crotalid venom. In addition, the presence of disintegrin-like and Cys-rich domains in snake venom metalloproteinases with diverse biological activities suggests that these domains may be important for their function. © 2002 Elsevier Science Ltd. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0003-9861(02)00447-2 | |
dc.source | Scopus | |
dc.subject | Disintegrin | |
dc.subject | Elapid | |
dc.subject | Metalloproteinase | |
dc.subject | Prothrombin activator | |
dc.subject | Snake venom | |
dc.type | Article | |
dc.contributor.department | ANATOMY | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.description.doi | 10.1016/S0003-9861(02)00447-2 | |
dc.description.sourcetitle | Archives of Biochemistry and Biophysics | |
dc.description.volume | 408 | |
dc.description.issue | 1 | |
dc.description.page | 87-92 | |
dc.description.coden | ABBIA | |
dc.identifier.isiut | 000179506700010 | |
Appears in Collections: | Staff Publications |
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