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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.brainres.2004.05.055
DC FieldValue
dc.titleExpression of glutamate receptors and calcium-binding proteins in the retina of streptozotocin-induced diabetic rats
dc.contributor.authorNg, Y.-K.
dc.contributor.authorZeng, X.-X.
dc.contributor.authorLing, E.-A
dc.date.accessioned2012-06-08T09:23:27Z
dc.date.available2012-06-08T09:23:27Z
dc.date.issued2004
dc.identifier.citationNg, Y.-K., Zeng, X.-X., Ling, E.-A (2004). Expression of glutamate receptors and calcium-binding proteins in the retina of streptozotocin-induced diabetic rats. Brain Research 1018 (1) : 66-72. ScholarBank@NUS Repository. https://doi.org/10.1016/j.brainres.2004.05.055
dc.identifier.issn00068993
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/33555
dc.description.abstractThis study was aimed to investigate the expression of glutamate receptors and calcium-binding proteins in 1- and 4-month/s (mo) streptozotocin (STZ)-induced diabetic rats. Upregulation of glutamate receptors' [N-methyl-D-aspartate receptor (NMDAR)1 and GluR2/3] immunoreactivities was observed in the ganglion, amacrine and bipolar cells as well as in the inner and outer plexiform layers (IPL and OPL) in 1 mo diabetes and was further enhanced at 4 mo. Immunoreactivity of calcium-binding proteins (calbindin and parvalbumin) was also concomitantly increased. The present results suggest that upregulation of glutamate receptors and calcium-binding proteins may reflect changes of the glutamate and calcium metabolism in the diabetic retina. It is speculated that the above changes in the IPL and OPL may be linked to alteration of synaptic transmission in the diabetic retina. © 2004 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.brainres.2004.05.055
dc.sourceScopus
dc.subjectCalcium-binding protein
dc.subjectDiabetes
dc.subjectGlutamate receptor
dc.subjectRetina
dc.subjectRetina and photoreceptors
dc.subjectSensory Systems
dc.typeArticle
dc.contributor.departmentANATOMY
dc.description.doi10.1016/j.brainres.2004.05.055
dc.description.sourcetitleBrain Research
dc.description.volume1018
dc.description.issue1
dc.description.page66-72
dc.description.codenBRREA
dc.identifier.isiut000223094100009
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