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Title: Nitric oxide induces macrophage apoptosis following traumatic brain injury in rats
Authors: Lu, J. 
Moochhala, S. 
Shirhan, M. 
Ng, K.C.
Tan, M.H.
Teo, A.L.
Ling, E.A. 
Keywords: Aminoguanidine
Inducible NO synthase
Lateral fluid percussive brain injury
Transferase d-UTP nick-end labeling
Issue Date: 2003
Citation: Lu, J., Moochhala, S., Shirhan, M., Ng, K.C., Tan, M.H., Teo, A.L., Ling, E.A. (2003). Nitric oxide induces macrophage apoptosis following traumatic brain injury in rats. Neuroscience Letters 339 (2) : 147-150. ScholarBank@NUS Repository.
Abstract: This study examined the apoptotic mechanisms of macrophages following a lateral fluid percussive brain injury. A marked induction of inducible NO synthase (iNOS) immunoexpression was observed in brain macrophages in the subarachnoid space and lateral ventricles ipsilateral to the injury. Numerous apoptotic macrophages occurred in the same region 7 days after the injury as shown by in situ terminal transferase d-UTP nick-end labeling (TUNEL) and caspase-3 immunohistochemistry. Double immunofluorescence staining showed that only a small number of TUNEL positive cells were iNOS positive; many TUNEL positive cells, however, were observed in the vicinity of iNOS positive cells. Administration of aminoguanidine resulted in a marked reduction of apoptotic cells in the lesioned area suggesting that overproduction of NO is linked to diminution of brain macrophages by apoptosis. © 2003 Elsevier Science Ireland Ltd. All rights reserved.
Source Title: Neuroscience Letters
ISSN: 03043940
DOI: 10.1016/S0304-3940(03)00003-X
Appears in Collections:Staff Publications

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