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|Title:||A comparative study of NADPH-diaphorase in the sympathetic preganglionic neurons of the upper thoracic cord between spontaneously hypertensive rats and Wistar-Kyoto rats||Authors:||Tang, F.R.
Superior cervical ganglion
Sympathetic preganglionic neuron
|Issue Date:||1995||Citation:||Tang, F.R., Tan, C.K., Ling, E.A. (1995). A comparative study of NADPH-diaphorase in the sympathetic preganglionic neurons of the upper thoracic cord between spontaneously hypertensive rats and Wistar-Kyoto rats. Brain Research 691 (1-2) : 153-159. ScholarBank@NUS Repository. https://doi.org/10.1016/0006-8993(95)00658-D||Abstract:||With retrograde tracing using fluorogold injection into the superior cervical ganglion and nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) histochemistry, the present comparative study revealed that the retrogradely labelled neurons in n. intermediolateralis pars funicularis (ILf) and N. intermediolateralis pars principalis (ILp) of the autonomic region in the upper thoracid cord exhibited a much stronger reactivity for NADPH-diaphorase in Wistar-Kyoto (WKY) rats than those in spontaneously hypertensive rats (SHR). It was found that in ILf in WKY rats, 77.62% of the fluorogold-labelled neurons were NADPH-d positive, while in SHR, only 56.43% of the labelled neurons were NADPH-d positive. The frequency distribution of NADPH-d positive retrogradely labelled neurons was significantly reduced in Ilf of the spinal cord of SHR (U-test: P< 0.01). In ILp in WKY rats, 65.25% of fluorogold-labelled neurons were NADPH-d positive in WKY rats, while in SHR, only 56.28% of the labelled neurons were NADPH-d positive. Although the difference (P> 0.05) in the frequency of NADPH-d positive neurons in ILp between the two strains of rats was not significant, the reductions in SHR seemed considerable. Examination of the pregnagnlionic sympathetic trunk and the superior cervical ganglion between SHR and WKY rats revealed that virtually all the NADPH-d positive fibers were derived from the sympathetic preganglionic neurons. In SHR, the NADPH-d positive fibers were not as intensely stained as those of WKY rats. This preliminary results suggest that nitric oxide, as an inhibitory neurotransmitter, may be implicated in the onst of hypertension.||Source Title:||Brain Research||URI:||http://scholarbank.nus.edu.sg/handle/10635/33515||ISSN:||00068993||DOI:||10.1016/0006-8993(95)00658-D|
|Appears in Collections:||Staff Publications|
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