Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0304-3940(03)00572-X
DC FieldValue
dc.titleResponse of neurons and microglia/macrophages in the area postrema of adult rats following exposure to hypobaric hypoxia
dc.contributor.authorAl-Saleh, S.S.
dc.contributor.authorKaur, C.
dc.contributor.authorLing, E.A.
dc.date.accessioned2012-06-08T09:22:08Z
dc.date.available2012-06-08T09:22:08Z
dc.date.issued2003
dc.identifier.citationAl-Saleh, S.S., Kaur, C., Ling, E.A. (2003). Response of neurons and microglia/macrophages in the area postrema of adult rats following exposure to hypobaric hypoxia. Neuroscience Letters 346 (1-2) : 77-80. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3940(03)00572-X
dc.identifier.issn03043940
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/33473
dc.description.abstractThe response of neurons and microglia/macrophages in the area postrema (AP) was examined in adult rats following exposure to hypobaric hypoxia. In this connection, immunoexpression of complement type 3 (CR3) receptors, major histocompatibility complex (MHC) class I and II antigens and ED1 antigens on the macrophages/microglia was downregulated immediately after the hypoxic insult. However, it showed an upregulation at 7-14 days and was comparable to the controls thereafter. At the ultrastructural level, swollen axons showing disruption of their myelin sheaths were observed between 7 and 14 days. At this time interval microglia/macrophages in the AP were observed to phagocytose such axons. Neurons did not show any structural alteration at any time interval following hypoxic exposure and appeared comparable to the neurons in the control AP. It is suggested that alterations in CR3 receptors, ED1, and MHC I and II antigens on the macrophages/microglia in hypobaric hypoxia were in response to axonal changes. Increased permeability of blood vessels following hypoxia may also play a role in activation of these cells as they would be involved in the clearance of extravasated serum derived substances. © 2003 Elsevier Science Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0304-3940(03)00572-X
dc.sourceScopus
dc.subjectArea postrema
dc.subjectComplement type 3 receptors
dc.subjectED1 antigens
dc.subjectHypobaric hypoxia
dc.subjectMajor histocompatibility complex class I and II antigens
dc.typeArticle
dc.contributor.departmentANATOMY
dc.description.doi10.1016/S0304-3940(03)00572-X
dc.description.sourcetitleNeuroscience Letters
dc.description.volume346
dc.description.issue1-2
dc.description.page77-80
dc.description.codenNELED
dc.identifier.isiut000184192200020
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

5
checked on Aug 3, 2020

WEB OF SCIENCETM
Citations

5
checked on Aug 3, 2020

Page view(s)

104
checked on Aug 4, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.