Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbcan.2009.07.004
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dc.titleMolecular pathology of RUNX3 in human carcinogenesis
dc.contributor.authorSubramaniam, M.M.
dc.contributor.authorChan, J.Y.
dc.contributor.authorSalto-Tellez, M.
dc.contributor.authorQuek, T.
dc.contributor.authorYeoh, K.G.
dc.contributor.authorIto, K.
dc.date.accessioned2012-05-29T02:22:21Z
dc.date.available2012-05-29T02:22:21Z
dc.date.issued2009
dc.identifier.citationSubramaniam, M.M., Chan, J.Y., Salto-Tellez, M., Quek, T., Yeoh, K.G., Ito, K. (2009). Molecular pathology of RUNX3 in human carcinogenesis. Biochimica et Biophysica Acta - Reviews on Cancer 1796 (2) : 315-331. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbcan.2009.07.004
dc.identifier.issn0304419X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/33221
dc.description.abstractA major goal of molecular biology is to elucidate the mechanisms underlying cancer development and progression in order to achieve early detection, better diagnosis and staging and novel preventive and therapeutic strategies. We feel that an understanding of Runt-related transcription factor 3 (RUNX3)-regulated biological pathways will directly impact our knowledge of these areas of human carcinogenesis. The RUNX3 transcription factor is a downstream effector of the transforming growth factor-beta (TGF-β) signaling pathway, and has a critical role in the regulation of cell proliferation and cell death by apoptosis, and in angiogenesis, cell adhesion and invasion. We previously identified RUNX3 as a major gastric tumor suppressor by establishing a causal relationship between loss of function and gastric carcinogenesis. More recently, we showed that RUNX3 functions as a bona fide initiator of colonic carcinogenesis by linking the Wnt oncogenic and TGF-β tumor suppressive pathways. Apart from gastric and colorectal cancers, a multitude of epithelial cancers exhibit inactivation of RUNX3, thereby making it a putative tumor suppressor in human neoplasia. This review highlights our current understanding of the molecular mechanisms of RUNX3 inactivation in the context of cancer development and progression. © 2009 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bbcan.2009.07.004
dc.sourceScopus
dc.subjectApoptosis
dc.subjectCancer
dc.subjectCarcinogenesis
dc.subjectEpigenetics
dc.subjectMethylation
dc.subjectOncogene
dc.subjectPreneoplastic lesions
dc.subjectProtein expression
dc.subjectRUNX
dc.subjectRUNX3
dc.subjectTumor suppressor gene
dc.typeReview
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentPATHOLOGY
dc.contributor.departmentMEDICINE
dc.contributor.departmentNATIONAL UNIVERSITY MEDICAL INSTITUTES
dc.description.doi10.1016/j.bbcan.2009.07.004
dc.description.sourcetitleBiochimica et Biophysica Acta - Reviews on Cancer
dc.description.volume1796
dc.description.issue2
dc.description.page315-331
dc.description.codenBBACE
dc.identifier.isiut000270767600021
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