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Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/33168
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dc.titleMolecular response of leukemia HL-60 cells to genistein treatment, a proteomics study
dc.contributor.authorZhang, D.
dc.contributor.authorKoay, E.S.-C.
dc.contributor.authorTai, Y.-C.
dc.contributor.authorWong, C.-H.S.
dc.contributor.authorChen, C.-S.
dc.contributor.authorTai, L.-K.
dc.date.accessioned2012-05-29T02:21:28Z
dc.date.available2012-05-29T02:21:28Z
dc.date.issued2007
dc.identifier.citationZhang, D., Koay, E.S.-C., Tai, Y.-C., Wong, C.-H.S., Chen, C.-S., Tai, L.-K. (2007). Molecular response of leukemia HL-60 cells to genistein treatment, a proteomics study. Leukemia Research 31 (1) : 75-82. ScholarBank@NUS Repository.
dc.identifier.issn01452126
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/33168
dc.description.abstractGenistein (GEN) is a natural protein tyrosine kinase inhibitor. We analyzed the molecular response of HL-60 cells to GEN treatment by gel-based proteomics approach. Fourteen differentially expressed proteins which are functionally involved in metabolism, cell signaling, RNA processing, cell proliferation and motility, and chaperones were identified. Both the dose- and time-dependent up-regulation of Hsp70 protein 8 and heterogeneous nuclear ribonucleoprotein (hnRNP) H1, and the down-regulation of Rab14, hnRNP C and stathmin-1 by GEN were verified by immunoblot analysis. Our novel findings provide insightful clues to the potential therapeutic targets for leukemia treatment in diverse tyrosine kinase-dependent cellular pathways. © 2006 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.leukres.2006.02.026
dc.sourceScopus
dc.subjectCell cycle arrest
dc.subjectGenistein
dc.subjectLeukemia HL-60
dc.subjectProteomics
dc.subjectTyrosine kinase
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.contributor.departmentPATHOLOGY
dc.description.sourcetitleLeukemia Research
dc.description.volume31
dc.description.issue1
dc.description.page75-82
dc.description.codenLERED
dc.identifier.isiut000242797900012
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