Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.acthis.2008.07.007
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dc.titleCofilin immunolabelling correlates with depth of invasion in gastrointestinal endocrine cell tumors
dc.contributor.authorYan, B.
dc.contributor.authorWang, S.
dc.contributor.authorLee, C.K.
dc.contributor.authorSalto-Tellez, M.
dc.contributor.authorKumarasinghe, M.P.
dc.contributor.authorYap, C.T.
dc.contributor.authorKoh, S.
dc.contributor.authorOmar, M.F.
dc.date.accessioned2012-05-29T02:21:01Z
dc.date.available2012-05-29T02:21:01Z
dc.date.issued2010
dc.identifier.citationYan, B., Wang, S., Lee, C.K., Salto-Tellez, M., Kumarasinghe, M.P., Yap, C.T., Koh, S., Omar, M.F. (2010). Cofilin immunolabelling correlates with depth of invasion in gastrointestinal endocrine cell tumors. Acta Histochemica 112 (1) : 101-106. ScholarBank@NUS Repository. https://doi.org/10.1016/j.acthis.2008.07.007
dc.identifier.issn00651281
dc.identifier.issn16180372
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/33140
dc.description.abstractGastrointestinal endocrine cell tumors are a heterogeneous population of lesions believed to arise from neuroendocrine cells of the gastrointestinal mucosa. The current classification of these tumors is based on tumor size, microscopic features and clinical evidence of metastasis. Although diagnostic categories generally correlate with prognosis, molecular prognostic markers will be clinically useful adjuncts. Cofilin has been implicated in tumor invasion, and its immunolocalisation was studied in gastrointestinal endocrine cell tumors. The immunolocalisation of cofilin was studied by immunohistochemistry in 34 formalin-fixed, paraffin wax-embedded gastrointestinal endocrine cell tumors using a tissue microarray platform. A significant correlation was found between high cofilin immunolabelling and the depth of invasion (p<0.05). Our findings suggest that cofilin might be useful clinically as a molecular prognostic adjunct in the evaluation of gastrointestinal endocrine cell tumors. © 2008 Elsevier GmbH. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.acthis.2008.07.007
dc.sourceScopus
dc.subjectCofilin
dc.subjectGastrointestinal endocrine cell tumor
dc.subjectImmunohistochemistry
dc.typeArticle
dc.contributor.departmentPATHOLOGY
dc.contributor.departmentPHYSIOLOGY
dc.contributor.departmentNATIONAL UNIVERSITY MEDICAL INSTITUTES
dc.description.doi10.1016/j.acthis.2008.07.007
dc.description.sourcetitleActa Histochemica
dc.description.volume112
dc.description.issue1
dc.description.page101-106
dc.description.codenAHISA
dc.identifier.isiut000274528200012
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