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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neubiorev.2005.05.008
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dc.titleCholecystokinin-2 (CCK2) receptor-mediated anxiety-like behaviors in rats
dc.contributor.authorWang, H.
dc.contributor.authorWong, P.T.-H.
dc.contributor.authorZhu, Y.Z.
dc.contributor.authorSpiess, J.
dc.date.accessioned2012-04-02T07:43:58Z
dc.date.available2012-04-02T07:43:58Z
dc.date.issued2005
dc.identifier.citationWang, H., Wong, P.T.-H., Zhu, Y.Z., Spiess, J. (2005). Cholecystokinin-2 (CCK2) receptor-mediated anxiety-like behaviors in rats. Neuroscience and Biobehavioral Reviews 29 (8) : 1361-1373. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neubiorev.2005.05.008
dc.identifier.issn01497634
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/32201
dc.description.abstractCholecystokinin (CCK) is a neurotransmitter in the brain closely related to anxiety. Of the two CCK receptor subtypes, CCK2 receptors are most implicated in the control of anxiety-related behavior. CCK2 receptor activation causes anxiogenic effects while the blockade of this receptor has anxiolytic effects. This review focuses on the molecular mechanisms of CCK 2 receptors underlying anxiety-related behaviors of PVG hooded and Spraque-Dawley (SD) rats in two anxiety models (elevated plus-maze [EPM] and cat exposure test). PVG hooded rats showed prolonged freezing behavior in the cat exposure test while SD rats showed very low levels of freezing. A CCK 2 receptor antagonist (LY225910) attenuated freezing behavior in PVG hooded rats while a CCK2 receptor agonist (CCK-4) increased freezing behavior in SD rats. In contrast, the two strains behaved similarly on the EPM. CCK-4 caused a pronounced anxiogenic effect in PVG hooded rats but only a slight effect in SD rats. CCK2 antagonists also showed more pronounced anxiolytic effects in PVG hooded rats than in SD rats. CCK2 receptor expression was greater in PVG hooded than in SD rats in the cortex and hippocampus. Genetic studies also demonstrated four differences in the DNA sequence of the CCK2 receptor gene between the two rat strains. © 2005 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.neubiorev.2005.05.008
dc.sourceScopus
dc.subjectAnimal models
dc.subjectAnxiety
dc.subjectCCK2receptor
dc.subjectGene expression
dc.typeConference Paper
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/j.neubiorev.2005.05.008
dc.description.sourcetitleNeuroscience and Biobehavioral Reviews
dc.description.volume29
dc.description.issue8
dc.description.page1361-1373
dc.description.codenNBRED
dc.identifier.isiut000233140100019
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