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Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/32131
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dc.titleSimultaneous estimation of serum concentrations of dapsone, monoacetyldapsone, and pyrimethamine in Chinese men on maloprim for malaria prophylaxis using reversed-phase high performance liquid chromatography
dc.contributor.authorLee, H.S.
dc.contributor.authorTi, T.Y.
dc.contributor.authorLee, P.S.
dc.contributor.authorYap, C.L.
dc.date.accessioned2012-04-02T07:42:32Z
dc.date.available2012-04-02T07:42:32Z
dc.date.issued1985
dc.identifier.citationLee, H.S., Ti, T.Y., Lee, P.S., Yap, C.L. (1985). Simultaneous estimation of serum concentrations of dapsone, monoacetyldapsone, and pyrimethamine in Chinese men on maloprim for malaria prophylaxis using reversed-phase high performance liquid chromatography. Therapeutic Drug Monitoring 7 (4) : 415-420. ScholarBank@NUS Repository.
dc.identifier.issn01634356
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/32131
dc.description.abstractA reversed-phase high performance liquid chromatography method was developed to simultaneously estimate serum concentrations of dapsone (DDS), monoacetyldapsone (MADDS), and pyrimethamine (PYR) in 34 young adult Chinese men after they had taken the sixth weekly dose of Maloprim for malaria prophylaxis. Serum concentrations of DDS, MADDS, and PYR after 24 h were (mean ± SEM) 374 ± 31.1, 310 ± 30.4, and 121 ± 7.9 ng/ml, respectively. The 72-h serum concentrations of DDS, MADDS, and PYR were (mean ± SEM) 134 ± 21.6, 115 ± 17.9, and 80 ± 7.2 ng/ml, respectively. Serum concentrations of DDS and MADDS in many subjects after 120 h were
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.description.sourcetitleTherapeutic Drug Monitoring
dc.description.volume7
dc.description.issue4
dc.description.page415-420
dc.description.codenTDMOD
dc.identifier.isiutNOT_IN_WOS
dc.published.stateUnpublished
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