Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0379-0738(01)00476-5
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dc.titleThe 3-week sulphasalazine syndrome strikes again
dc.contributor.authorLau, G.
dc.contributor.authorKwan, C.
dc.contributor.authorChong, S.M.
dc.date.accessioned2012-02-01T05:23:43Z
dc.date.available2012-02-01T05:23:43Z
dc.date.issued2001
dc.identifier.citationLau, G., Kwan, C., Chong, S.M. (2001). The 3-week sulphasalazine syndrome strikes again. Forensic Science International 122 (2-3) : 79-84. ScholarBank@NUS Repository. https://doi.org/10.1016/S0379-0738(01)00476-5
dc.identifier.issn03790738
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/30351
dc.description.abstractA 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called '3-week sulphasalazine syndrome', a rare, but often fatal, immunoallergic reaction to sulphasalazine. Copyright © 2001 Elsevier Science Ireland Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0379-0738(01)00476-5
dc.sourceScopus
dc.subjectAcute myocarditis
dc.subjectBone marrow necrosis
dc.subjectMassive hepatocellular necrosis
dc.subjectSero-negative rheumatoid arthritis
dc.subjectSulphasalazine
dc.subjectTubulo-interstitial nephritis
dc.typeArticle
dc.contributor.departmentPATHOLOGY
dc.description.doi10.1016/S0379-0738(01)00476-5
dc.description.sourcetitleForensic Science International
dc.description.volume122
dc.description.issue2-3
dc.description.page79-84
dc.description.codenFSIND
dc.identifier.isiut000172352800001
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