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|Title:||Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentration and reduction of intracellular milieu||Authors:||Clement, M.-V.
Cellular redox state
|Issue Date:||1998||Citation:||Clement, M.-V., Ponton, A., Pervaiz, S. (1998). Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentration and reduction of intracellular milieu. FEBS Letters 440 (1-2) : 13-18. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(98)01410-0||Abstract:||Hydrogen peroxide (H2O2) is considered to be a mediator of apoptotic cell death but the mechanism by which it induces apoptosis is unclear. Here, we show that cells undergoing apoptosis from exposure to H2O2 display a significant decrease in intracellular concentration of superoxide (O-2) which is associated with a reduction of the intracellular milieu, as measured by an increase in the GSH/GSSG ratio and a decrease in intracellular pH. The notion that a decrease in intracellular O-2 concentration triggers apoptosis is supported by the observation that H2O2-mediated apoptosis could be retarded in cells in which the intracellular O-2 concentration is maintained at or above the cellular baseline level by inhibition of the major O-2 scavenger superoxide dismutase (Cu/Zn SOD). Taken together, our observations indicate that a decrease in the intracellular O-2 concentration, reduction and acidification of the intracellular milieu constitute a signal for H2O2-mediated apoptosis, thereby inducing a reductive as opposed to an oxidative stress. Copyright (C) 1998 Federation of European Biochemical Societies.||Source Title:||FEBS Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/29722||ISSN:||00145793||DOI:||10.1016/S0014-5793(98)01410-0|
|Appears in Collections:||Staff Publications|
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