Please use this identifier to cite or link to this item:
|Title:||Dorsal hippocampus field CA1 pyramidal cell responses to a persistent versus an acute nociceptive stimulus and their septal modulation||Authors:||Khanna, S.||Keywords:||dorsal hippocampus
medial septal-vertical limb of diagonal band of Broca
pyramidal cell depression
selective cell excitation
|Issue Date:||1997||Citation:||Khanna, S. (1997). Dorsal hippocampus field CA1 pyramidal cell responses to a persistent versus an acute nociceptive stimulus and their septal modulation. Neuroscience 77 (3) : 713-721. ScholarBank@NUS Repository. https://doi.org/10.1016/S0306-4522(96)00456-3||Abstract:||In urethane anaesthetized rats subcutaneous formalin injection in the right hind paw, a model of persistent pain, produced (i) a prolonged increase in the period of field rhythmic sinusoidal (or theta) activity, (ii) a depression of dorsal hippocampal field CA1 pyramidal cell synaptic excitabilitv (mean peak depression of population spike amplitude being 50 ± 6%) observed to the 60th min post injection, and (iii) a persistent decrease in extracellular activity of the majority of CA1 pyramidal cells (15/20 or 75%) with only a small percentage excited (5/20 or 25%). In contrast an intense noxious heat stimulus applied briefly to the distal end of the tail evoked a short duration increase in period of theta activation and suppression of pyramidal cell responses. With this acute stimulus the proportion of CA1 pyramidal cells excited (8/16) were similar to that suppressed (7/16). Finally, electrolytic lesions centred in the medial septal-vertical limb of diagonal band of Broca (or septal region) prevented a noxious stimulus-induced theta and depression of CA1 pvramidal cell responses. Rather, in such lesioned animals noxious stimulation excited the majority CA1 complex spike cells studied (8/10). The above data are consistent with the notion that septohippocampal inputs are involved in noxious stimulus-induced CA1 pyramidal cell suppression. The formalin injection-induced selective activation of CA1 complex spike cells against a background of widespread pyramidal cell suppression might produce a 'signal to noise' contributory to nociceptive processing in limbic structures. Such a processing might be involved in the affective-motivational component of pain.||Source Title:||Neuroscience||URI:||http://scholarbank.nus.edu.sg/handle/10635/29647||ISSN:||03064522||DOI:||10.1016/S0306-4522(96)00456-3|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Apr 15, 2019
WEB OF SCIENCETM
checked on Apr 15, 2019
checked on Apr 22, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.