Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.freeradbiomed.2006.11.024
DC FieldValue
dc.titleZinc supplementation inhibits lipid peroxidation and the development of atherosclerosis in rabbits fed a high cholesterol diet
dc.contributor.authorJenner, A.
dc.contributor.authorNing, P.
dc.contributor.authorHalliwell, B.
dc.contributor.authorRen, M.
dc.contributor.authorRajendran, R.
dc.contributor.authorWatt, F.
dc.contributor.authorHuat, B.T.K.
dc.date.accessioned2011-11-29T06:11:24Z
dc.date.available2011-11-29T06:11:24Z
dc.date.issued2007
dc.identifier.citationJenner, A., Ning, P., Halliwell, B., Ren, M., Rajendran, R., Watt, F., Huat, B.T.K. (2007). Zinc supplementation inhibits lipid peroxidation and the development of atherosclerosis in rabbits fed a high cholesterol diet. Free Radical Biology and Medicine 42 (4) : 559-566. ScholarBank@NUS Repository. https://doi.org/10.1016/j.freeradbiomed.2006.11.024
dc.identifier.issn08915849
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28953
dc.description.abstractDeveloping atherosclerotic lesions in hypercholesterolemic rabbits are depleted in zinc, while iron accumulates. This study examined the influence of zinc supplementation on the development of atherosclerosis and used isotope dilution gas chromatography-mass spectrometry techniques to measure biomarkers of oxidative lipid damage in atherosclerotic rabbit aorta. Our previous method for F2-isoprostane measurement was adapted to include the quantitation of cholesterol oxidation products in the same sample. Two groups of New Zealand white rabbits were fed a high cholesterol (1% w/w) diet and one group was also supplemented with zinc (1 g/kg) for 8 weeks. Controls were fed a normal diet. Zinc supplementation did not significantly alter the increase in total plasma cholesterol levels observed in animals fed high cholesterol. However, in cholesterol-fed animals zinc supplementation significantly reduced the accumulation of total cholesterol levels in aorta which was accompanied by a significant reduction in average aortic lesion cross-sectional areas of the animals. Elevated levels of cholesterol oxidation products (5,6-α and β cholesterol epoxides, 7β-hydroxycholesterol, 7-ketocholesterol) in aorta and total F2-isoprostanes in plasma and aorta of rabbits fed a cholesterol diet were significantly decreased by zinc supplementation. Our data indicate that zinc has an antiatherogenic effect, possibly due to a reduction in iron-catalyzed free radical reactions. © 2006 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.freeradbiomed.2006.11.024
dc.sourceScopus
dc.subjectAtherosclerosis
dc.subjectCholesterol
dc.subjectF2-Isoprostanes
dc.subjectLipid peroxidation
dc.subjectOxysterol
dc.subjectZinc
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentPHYSICS
dc.description.doi10.1016/j.freeradbiomed.2006.11.024
dc.description.sourcetitleFree Radical Biology and Medicine
dc.description.volume42
dc.description.issue4
dc.description.page559-566
dc.description.codenFRBME
dc.identifier.isiut000244279200014
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