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Title: Zinc supplementation decreases the development of atherosclerosis in rabbits
Authors: Ren, M. 
Rajendran, R.
Watt, F. 
Ning, P.
Jenner, A. 
Halliwell, B. 
Tan, Kwong Huat B. 
Choon, Nam O. 
Keywords: Atherosclerosis
Free radicals
Lesion area
Nuclear microscopy
Zinc supplement
Issue Date: 2006
Citation: Ren, M., Rajendran, R., Watt, F., Ning, P., Jenner, A., Halliwell, B., Tan, Kwong Huat B., Choon, Nam O. (2006). Zinc supplementation decreases the development of atherosclerosis in rabbits. Free Radical Biology and Medicine 41 (2) : 222-225. ScholarBank@NUS Repository.
Abstract: Developing atherosclerotic plaques in cholesterol-fed rabbits are enriched in iron but depleted in zinc. In order to examine further the role of zinc, New Zealand White rabbits were fed a high-cholesterol 1% (w/w) diet with zinc (1 g/kg) supplementation for 8 weeks. After the 8-week period, the average atherosclerotic lesion cross-sectional areas in the aortas of the animals fed with the zinc supplement were significantly decreased (1.0 mm2) compared with lesion areas of the animals fed only on the high-cholesterol diet (3.1 mm2). Using nuclear microscopy, a technique for mapping and measuring trace elements in tissue sections, lesion zinc levels (24 ppm) were observed to be unchanged in the zinc-fed rabbits compared to controls. However, average lesion Fe levels in the zinc-fed group were measured at 32 ppm, whereas in the control group the average Fe levels were significantly higher at 43 ppm (P = 0.03). Our data support the concept that zinc may have an antiatherogenic effect by decreasing iron levels in the lesion, possibly leading to inhibition of iron-catalyzed free radical reactions. © 2006 Elsevier Inc. All rights reserved.
Source Title: Free Radical Biology and Medicine
ISSN: 08915849
DOI: 10.1016/j.freeradbiomed.2006.03.017
Appears in Collections:Staff Publications

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