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Title: | Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: A possible role in statin-induced hepatotoxicity? | Authors: | Tavintharan, S. Lim, S.C. Ong, C.N. Jeyaseelan, K. Sivakumar, M. Sum, C.F. |
Keywords: | Hepatotoxicity Oxidative stress Statins Transaminitis Ubiquinone |
Issue Date: | 2007 | Citation: | Tavintharan, S., Lim, S.C., Ong, C.N., Jeyaseelan, K., Sivakumar, M., Sum, C.F. (2007). Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: A possible role in statin-induced hepatotoxicity?. Toxicology and Applied Pharmacology 223 (2) : 173-179. ScholarBank@NUS Repository. | Abstract: | Lowering of low-density lipoprotein cholesterol is well achieved by 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins). Statins inhibit the conversion of HMG-CoA to mevalonate, a precursor for cholesterol and coenzyme Q10 (CoQ10). In HepG2 cells, simvastatin decreased mitochondrial CoQ10 levels, and at higher concentrations was associated with a moderately higher degree of cell death, increased DNA oxidative damage and a reduction in ATP synthesis. Supplementation of CoQ10, reduced cell death and DNA oxidative stress, and increased ATP synthesis. It is suggested that CoQ10 deficiency plays an important role in statin-induced hepatopathy, and that CoQ10 supplementation protects HepG2 cells from this complication. © 2007 Elsevier Inc. All rights reserved. | Source Title: | Toxicology and Applied Pharmacology | URI: | http://scholarbank.nus.edu.sg/handle/10635/28907 | ISSN: | 0041008X 10960333 |
Appears in Collections: | Staff Publications |
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