Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bpc.2005.10.011
DC FieldValue
dc.titleInhibition of DNA hybridization by small metal nanoparticles
dc.contributor.authorYang, J.
dc.contributor.authorLee, J.Y.
dc.contributor.authorChow, G.-M.
dc.contributor.authorToo, H.-P.
dc.date.accessioned2011-11-29T06:10:19Z
dc.date.available2011-11-29T06:10:19Z
dc.date.issued2006
dc.identifier.citationYang, J., Lee, J.Y., Chow, G.-M., Too, H.-P. (2006). Inhibition of DNA hybridization by small metal nanoparticles. Biophysical Chemistry 120 (2) : 87-95. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bpc.2005.10.011
dc.identifier.issn03014622
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28859
dc.description.abstractThe inhibition of DNA hybridization by small metal nanoparticles has been examined in detail. DNA melting point analysis showed that the oligonucleotides adsorb strongly and nonspecifically on small metal nanoparticles, inhibiting the hybridization of complementary DNA sequences in common buffered solutions. The nonspecific interaction is even strong enough to disrupt pre-existing hydrogen bonds in short double-stranded DNA. The nonspecific interaction could be weakened by increasing the particle size. As an example, a core-shell assisted method was used to successfully assemble Pt nanoparticles by DNA hybridization that could not be done otherwise. © 2005 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bpc.2005.10.011
dc.sourceScopus
dc.subjectAssembly
dc.subjectDNA hybridization
dc.subjectNanoparticle
dc.subjectNon-specific interaction
dc.subjectOligonucleotide
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentMATERIALS SCIENCE AND ENGINEERING
dc.contributor.departmentSINGAPORE-MIT ALLIANCE
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1016/j.bpc.2005.10.011
dc.description.sourcetitleBiophysical Chemistry
dc.description.volume120
dc.description.issue2
dc.description.page87-95
dc.description.codenBICIA
dc.identifier.isiut000236316300002
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