Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mito.2006.07.006
DC FieldValue
dc.titleThe role of the mitochondrial permeability transition in cell death
dc.contributor.authorArmstrong, J.S.
dc.date.accessioned2011-11-29T05:59:20Z
dc.date.available2011-11-29T05:59:20Z
dc.date.issued2006
dc.identifier.citationArmstrong, J.S. (2006). The role of the mitochondrial permeability transition in cell death. Mitochondrion 6 (5) : 225-234. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mito.2006.07.006
dc.identifier.issn15677249
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28779
dc.description.abstractThe mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that occurs in response to increased calcium load and redox stress. Currently, two models of the MPT exist including the, largely hypothetical, native proteinaceous pore model and the oxidized inner membrane protein model which may reflect the extremes in a continuum of changes that occur to the inner membrane prior to its permeabilization. Here I discuss evidence that the MPT per se leads to necrosis, but not cytochrome c release and apoptosis. However, data also suggest that signaling crosstalk between the MPT and Bcl-2 family proteins occurs indicating an important role for the MPT in apoptosis. © 2006 Mitochondria Research Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.mito.2006.07.006
dc.sourceScopus
dc.subjectApoptosis
dc.subjectBcl-2
dc.subjectCyclosporine A
dc.subjectMitochondria
dc.subjectMitochondrial permeability transition
dc.subjectNecrosis
dc.subjectReactive oxygen species
dc.typeReview
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.mito.2006.07.006
dc.description.sourcetitleMitochondrion
dc.description.volume6
dc.description.issue5
dc.description.page225-234
dc.description.codenMITOC
dc.identifier.isiut000242521300001
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