Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.freeradbiomed.2007.08.026
DC FieldValue
dc.titleElevated F2-isoprostanes in thalassemic patients
dc.contributor.authorMatayatsuk, C.
dc.contributor.authorWilairat, P.
dc.contributor.authorLee, C.-Y.J.
dc.contributor.authorHalliwell, B.
dc.contributor.authorKalpravidh, R.W.
dc.contributor.authorSirankapracha, P.
dc.contributor.authorFucharoen, S.
dc.date.accessioned2011-11-29T02:59:54Z
dc.date.available2011-11-29T02:59:54Z
dc.date.issued2007
dc.identifier.citationMatayatsuk, C., Wilairat, P., Lee, C.-Y.J., Halliwell, B., Kalpravidh, R.W., Sirankapracha, P., Fucharoen, S. (2007). Elevated F2-isoprostanes in thalassemic patients. Free Radical Biology and Medicine 43 (12) : 1649-1655. ScholarBank@NUS Repository. https://doi.org/10.1016/j.freeradbiomed.2007.08.026
dc.identifier.issn08915849
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28566
dc.description.abstractThis study was aimed at investigating oxidative stress in thalassemic patients by measurement of the oxidative damage biomarker, F2-isoprostanes (F2-IsoPs), using gas chromatography-mass spectrometry. The results showed that the mean value of urinary F2-IsoPs, normalized with creatinine, in the thalassemic group was significantly higher than that from healthy subjects (3.38 ± 2.15 ng/mg creatinine vs 0.86 ± 0.55 ng/mg creatinine, respectively), and the mean value of plasma total F2-IsoPs in the thalassemic group was also significantly higher than that from healthy subjects (0.39 ± 0.15 ng/ml vs 0.18 ± 0.03 ng/ml, respectively). Serum ferritin, erythrocyte superoxide dismutase (SOD), glutathione peroxidase, glutathione, and TBARS levels after treatment of erythrocytes with H2O2 were also investigated, and serum ferritin and erythrocyte SOD levels were significantly higher in thalassemic patients. Our findings are consistent with oxidative stress in thalassemia patients. © 2007 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.freeradbiomed.2007.08.026
dc.sourceScopus
dc.subjectF2-isoprostanes
dc.subjectOxidative stress
dc.subjectThalassemia
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.freeradbiomed.2007.08.026
dc.description.sourcetitleFree Radical Biology and Medicine
dc.description.volume43
dc.description.issue12
dc.description.page1649-1655
dc.description.codenFRBME
dc.identifier.isiut000251670500009
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