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Title: Cautions in the use of biomarkers of oxidative damage; the vascular and antioxidant effects of dark soy sauce in humans
Authors: Lee, C.-Y.J. 
Isaac, H.B. 
Wang, H. 
Huang, S.H. 
Long, L.-H.
Jenner, A.M. 
Kelly, R.P.
Halliwell, B. 
Keywords: 8-OHdG
Esterified isoprostanes
Oxidative stress
Pulse wave velocity
Soy sauce
Issue Date: 2006
Citation: Lee, C.-Y.J., Isaac, H.B., Wang, H., Huang, S.H., Long, L.-H., Jenner, A.M., Kelly, R.P., Halliwell, B. (2006). Cautions in the use of biomarkers of oxidative damage; the vascular and antioxidant effects of dark soy sauce in humans. Biochemical and Biophysical Research Communications 344 (3) : 906-911. ScholarBank@NUS Repository.
Abstract: Dark soy sauce (DSS) is a powerful antioxidant in vitro. We investigated whether this effect could occur in vivo and improve vascular function. Healthy human subjects were given DSS or placebo meals in a randomized, crossover study. Blood and urine were sampled before and 1, 2, 3, and 4 h after the meal for F2-isoprostanes (total, free, and esterified) and 8OHdG measurements. Blood pressure, vascular augmentation index (AIx), and heart rate (HR) were also measured. Plasma total F2-isoprostanes significantly decreased 3 h after placebo and the decrease was greater for DSS. Plasma free and esterified F2-isoprostanes were also significantly decreased after DSS. Both placebo and DSS meals increased urinary F2-isoprostanes at 1 h but not thereafter, and lowered urinary 8OHdG levels, DBP and AIx, and increased HR. We conclude that DSS decreases lipid peroxidation in vivo. However, oxidative damage biomarkers changed after the placebo meal, a phenomenon to consider when designing interventional studies. © 2006.
Source Title: Biochemical and Biophysical Research Communications
ISSN: 0006291X
DOI: 10.1016/j.bbrc.2006.03.217
Appears in Collections:Staff Publications

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