Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.regpep.2006.07.002
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dc.titleEffects of losartan on angiotensin receptors in the hypertrophic rat heart
dc.contributor.authorSim, M.-K.
dc.contributor.authorChen, W.-S.
dc.date.accessioned2011-09-29T05:54:40Z
dc.date.available2011-09-29T05:54:40Z
dc.date.issued2006
dc.identifier.citationSim, M.-K., Chen, W.-S. (2006). Effects of losartan on angiotensin receptors in the hypertrophic rat heart. Regulatory Peptides 137 (3) : 140-146. ScholarBank@NUS Repository. https://doi.org/10.1016/j.regpep.2006.07.002
dc.identifier.issn01670115
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/27283
dc.description.abstractThe effects of losartan on angiotensin receptors in hypertrophic rat hearts were studied. The study was prompted by inconsistent findings of either an increase or decrease in the mRNA of the AT1 receptor in the hearts of cardiac hypertrophic rats treated with losartan, and a paucity of information on the effects of losartan on functional angiotensin receptors in the heart. Losartan, administered i.p. to aortic coarcted rats, dose-dependently attenuated the cardiac hypertrophy. Significant effect was observed with a dose of 2.72 μmol/kg/day for four days. Hypertrophy was accompanied by an increase in [125I]-Sar1-Ile8-angiotensin II binding sites (due mainly to an increase in AT2 binding) and AT2 receptor protein in cardiac ventricles of aortic coarcted rats. Treatment with effective anti-hypertrophic doses of losartan dose-dependently downregulated the [125I]-Sar1-Ile8-angiotensin II binding sites, constitutive AT1 receptor protein, and the over expressed AT2 receptor protein. It was suggested that the anti-cardiac hypertrophic action of losartan resulted from its ability to suppress the expression of both the basal and enhanced cardiac angiotensin receptors. This raises the question as to whether such drastic action could form the therapeutic basis for the use of losartan in cardiac pathologies. © 2006 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.regpep.2006.07.002
dc.sourceScopus
dc.subjectAngiotensins
dc.subjectAT1receptors
dc.subjectBinding studies
dc.subjectCardiac hypertrophy
dc.subjectLosartan
dc.subjectRats
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/j.regpep.2006.07.002
dc.description.sourcetitleRegulatory Peptides
dc.description.volume137
dc.description.issue3
dc.description.page140-146
dc.identifier.isiut000243310500007
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